Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: The TropNet severe malaria study

Florian Kurth; Michel Develoux; Matthieu Mechain; Jan Clerinx; Spinello Antinori; Ida E. Gjørup; Joaquím Gascon; Kristine Mørch; Emanuele Nicastri; Michael Ramharter; Alessandro Bartoloni; Leo Visser; Thierry Rolling; Philipp Zanger; Guido Calleri; Joaquín Salas-Coronas; Henrik Nielsen; Gudrun Just-Nübling; Andreas Neumayr; Anna Hachfeld; Matthias L. Schmid; Pietro Antonini; Peter Pongratz; Peter Kern; José Saraiva Da Cunha; Antoni Soriano-Arandes; Mirjam Schunk; Norbert Suttorp; Christoph Hatz; Thomas Zoller

doi:10.1093/cid/civ575

Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: The TropNet severe malaria study

Florian Kurth, Michel Develoux, Matthieu Mechain, Jan Clerinx, Spinello Antinori, Ida E. Gjørup, Joaquím Gascon, Kristine Mørch, Emanuele Nicastri, Michael Ramharter, Alessandro Bartoloni, Leo Visser, Thierry Rolling, Philipp Zanger, Guido Calleri, Joaquín Salas-Coronas, Henrik Nielsen, Gudrun Just-Nübling, Andreas Neumayr, Anna HachfeldMatthias L. Schmid, Pietro Antonini, Peter Pongratz, Peter Kern, José Saraiva Da Cunha, Antoni Soriano-Arandes, Mirjam Schunk, Norbert Suttorp, Christoph Hatz, Thomas Zoller

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Intravenous artesunate improves survival in severe malaria, but clinical trial data from nonendemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs quinine treatment. Artesunate reduced parasite clearance time and duration of intensive care unit and hospital treatment in European patients with imported severe malaria.

Original language	English
Pages (from-to)	1441-1444
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	61
Issue number	9
DOIs	https://doi.org/10.1093/cid/civ575
Publication status	Published - Nov 1 2015

Keywords

artesunate
clinical study
Plasmodium falciparum
quinine
severe malaria

ASJC Scopus subject areas

Infectious Diseases
Microbiology (medical)

Access to Document

10.1093/cid/civ575

Cite this

Kurth, F., Develoux, M., Mechain, M., Clerinx, J., Antinori, S., Gjørup, I. E., Gascon, J., Mørch, K., Nicastri, E., Ramharter, M., Bartoloni, A., Visser, L., Rolling, T., Zanger, P., Calleri, G., Salas-Coronas, J., Nielsen, H., Just-Nübling, G., Neumayr, A., ... Zoller, T. (2015). Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: The TropNet severe malaria study. Clinical Infectious Diseases, 61(9), 1441-1444. https://doi.org/10.1093/cid/civ575

Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe : The TropNet severe malaria study. / Kurth, Florian; Develoux, Michel; Mechain, Matthieu; Clerinx, Jan; Antinori, Spinello; Gjørup, Ida E.; Gascon, Joaquím; Mørch, Kristine; Nicastri, Emanuele; Ramharter, Michael; Bartoloni, Alessandro; Visser, Leo; Rolling, Thierry; Zanger, Philipp; Calleri, Guido; Salas-Coronas, Joaquín; Nielsen, Henrik; Just-Nübling, Gudrun; Neumayr, Andreas; Hachfeld, Anna; Schmid, Matthias L.; Antonini, Pietro; Pongratz, Peter; Kern, Peter; Saraiva Da Cunha, José; Soriano-Arandes, Antoni; Schunk, Mirjam; Suttorp, Norbert; Hatz, Christoph; Zoller, Thomas.

In: Clinical Infectious Diseases, Vol. 61, No. 9, 01.11.2015, p. 1441-1444.

Research output: Contribution to journal › Article › peer-review

Kurth, F, Develoux, M, Mechain, M, Clerinx, J, Antinori, S, Gjørup, IE, Gascon, J, Mørch, K, Nicastri, E, Ramharter, M, Bartoloni, A, Visser, L, Rolling, T, Zanger, P, Calleri, G, Salas-Coronas, J, Nielsen, H, Just-Nübling, G, Neumayr, A, Hachfeld, A, Schmid, ML, Antonini, P, Pongratz, P, Kern, P, Saraiva Da Cunha, J, Soriano-Arandes, A, Schunk, M, Suttorp, N, Hatz, C & Zoller, T 2015, 'Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: The TropNet severe malaria study', Clinical Infectious Diseases, vol. 61, no. 9, pp. 1441-1444. https://doi.org/10.1093/cid/civ575

Kurth, Florian ; Develoux, Michel ; Mechain, Matthieu ; Clerinx, Jan ; Antinori, Spinello ; Gjørup, Ida E. ; Gascon, Joaquím ; Mørch, Kristine ; Nicastri, Emanuele ; Ramharter, Michael ; Bartoloni, Alessandro ; Visser, Leo ; Rolling, Thierry ; Zanger, Philipp ; Calleri, Guido ; Salas-Coronas, Joaquín ; Nielsen, Henrik ; Just-Nübling, Gudrun ; Neumayr, Andreas ; Hachfeld, Anna ; Schmid, Matthias L. ; Antonini, Pietro ; Pongratz, Peter ; Kern, Peter ; Saraiva Da Cunha, José ; Soriano-Arandes, Antoni ; Schunk, Mirjam ; Suttorp, Norbert ; Hatz, Christoph ; Zoller, Thomas. / Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe : The TropNet severe malaria study. In: Clinical Infectious Diseases. 2015 ; Vol. 61, No. 9. pp. 1441-1444.

@article{d3c4064cb924404ba2113df7a63220b1,

title = "Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: The TropNet severe malaria study",

abstract = "Intravenous artesunate improves survival in severe malaria, but clinical trial data from nonendemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs quinine treatment. Artesunate reduced parasite clearance time and duration of intensive care unit and hospital treatment in European patients with imported severe malaria.",

keywords = "artesunate, clinical study, Plasmodium falciparum, quinine, severe malaria",

author = "Florian Kurth and Michel Develoux and Matthieu Mechain and Jan Clerinx and Spinello Antinori and Gj{\o}rup, {Ida E.} and Joaqu{\'i}m Gascon and Kristine M{\o}rch and Emanuele Nicastri and Michael Ramharter and Alessandro Bartoloni and Leo Visser and Thierry Rolling and Philipp Zanger and Guido Calleri and Joaqu{\'i}n Salas-Coronas and Henrik Nielsen and Gudrun Just-N{\"u}bling and Andreas Neumayr and Anna Hachfeld and Schmid, {Matthias L.} and Pietro Antonini and Peter Pongratz and Peter Kern and {Saraiva Da Cunha}, Jos{\'e} and Antoni Soriano-Arandes and Mirjam Schunk and Norbert Suttorp and Christoph Hatz and Thomas Zoller",

year = "2015",

month = nov,

day = "1",

doi = "10.1093/cid/civ575",

language = "English",

volume = "61",

pages = "1441--1444",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "NLM (Medline)",

number = "9",

}

TY - JOUR

T1 - Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe

T2 - The TropNet severe malaria study

AU - Kurth, Florian

AU - Develoux, Michel

AU - Mechain, Matthieu

AU - Clerinx, Jan

AU - Antinori, Spinello

AU - Gjørup, Ida E.

AU - Gascon, Joaquím

AU - Mørch, Kristine

AU - Nicastri, Emanuele

AU - Ramharter, Michael

AU - Bartoloni, Alessandro

AU - Visser, Leo

AU - Rolling, Thierry

AU - Zanger, Philipp

AU - Calleri, Guido

AU - Salas-Coronas, Joaquín

AU - Nielsen, Henrik

AU - Just-Nübling, Gudrun

AU - Neumayr, Andreas

AU - Hachfeld, Anna

AU - Schmid, Matthias L.

AU - Antonini, Pietro

AU - Pongratz, Peter

AU - Kern, Peter

AU - Saraiva Da Cunha, José

AU - Soriano-Arandes, Antoni

AU - Schunk, Mirjam

AU - Suttorp, Norbert

AU - Hatz, Christoph

AU - Zoller, Thomas

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Intravenous artesunate improves survival in severe malaria, but clinical trial data from nonendemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs quinine treatment. Artesunate reduced parasite clearance time and duration of intensive care unit and hospital treatment in European patients with imported severe malaria.

AB - Intravenous artesunate improves survival in severe malaria, but clinical trial data from nonendemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs quinine treatment. Artesunate reduced parasite clearance time and duration of intensive care unit and hospital treatment in European patients with imported severe malaria.

KW - artesunate

KW - clinical study

KW - Plasmodium falciparum

KW - quinine

KW - severe malaria

UR - http://www.scopus.com/inward/record.url?scp=84946721569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946721569&partnerID=8YFLogxK

U2 - 10.1093/cid/civ575

DO - 10.1093/cid/civ575

M3 - Article

C2 - 26187021

AN - SCOPUS:84946721569

VL - 61

SP - 1441

EP - 1444

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 9

ER -

Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: The TropNet severe malaria study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this