Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: The TropNet severe malaria study

Florian Kurth; Michel Develoux; Matthieu Mechain; Jan Clerinx; Spinello Antinori; Ida E. Gjørup; Joaquím Gascon; Kristine Mørch; Emanuele Nicastri; Michael Ramharter; Alessandro Bartoloni; Leo Visser; Thierry Rolling; Philipp Zanger; Guido Calleri; Joaquín Salas-Coronas; Henrik Nielsen; Gudrun Just-Nübling; Andreas Neumayr; Anna Hachfeld; Matthias L. Schmid; Pietro Antonini; Peter Pongratz; Peter Kern; José Saraiva Da Cunha; Antoni Soriano-Arandes; Mirjam Schunk; Norbert Suttorp; Christoph Hatz; Thomas Zoller

doi:10.1093/cid/civ575

Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: The TropNet severe malaria study

Florian Kurth, Michel Develoux, Matthieu Mechain, Jan Clerinx, Spinello Antinori, Ida E. Gjørup, Joaquím Gascon, Kristine Mørch, Emanuele Nicastri, Michael Ramharter, Alessandro Bartoloni, Leo Visser, Thierry Rolling, Philipp Zanger, Guido Calleri, Joaquín Salas-Coronas, Henrik Nielsen, Gudrun Just-Nübling, Andreas Neumayr, Anna HachfeldMatthias L. Schmid, Pietro Antonini, Peter Pongratz, Peter Kern, José Saraiva Da Cunha, Antoni Soriano-Arandes, Mirjam Schunk, Norbert Suttorp, Christoph Hatz, Thomas Zoller

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Intravenous artesunate improves survival in severe malaria, but clinical trial data from nonendemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs quinine treatment. Artesunate reduced parasite clearance time and duration of intensive care unit and hospital treatment in European patients with imported severe malaria.

Original language	English
Pages (from-to)	1441-1444
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	61
Issue number	9
DOIs	https://doi.org/10.1093/cid/civ575
Publication status	Published - Nov 1 2015

Keywords

artesunate
clinical study
Plasmodium falciparum
quinine
severe malaria

ASJC Scopus subject areas

Infectious Diseases
Microbiology (medical)

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10.1093/cid/civ575

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Kurth, F., Develoux, M., Mechain, M., Clerinx, J., Antinori, S., Gjørup, I. E., Gascon, J., Mørch, K., Nicastri, E., Ramharter, M., Bartoloni, A., Visser, L., Rolling, T., Zanger, P., Calleri, G., Salas-Coronas, J., Nielsen, H., Just-Nübling, G., Neumayr, A., ... Zoller, T. (2015). Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: The TropNet severe malaria study. Clinical Infectious Diseases, 61(9), 1441-1444. https://doi.org/10.1093/cid/civ575

Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe : The TropNet severe malaria study. / Kurth, Florian; Develoux, Michel; Mechain, Matthieu et al.

In: Clinical Infectious Diseases, Vol. 61, No. 9, 01.11.2015, p. 1441-1444.

Research output: Contribution to journal › Article › peer-review

Kurth, F, Develoux, M, Mechain, M, Clerinx, J, Antinori, S, Gjørup, IE, Gascon, J, Mørch, K, Nicastri, E, Ramharter, M, Bartoloni, A, Visser, L, Rolling, T, Zanger, P, Calleri, G, Salas-Coronas, J, Nielsen, H, Just-Nübling, G, Neumayr, A, Hachfeld, A, Schmid, ML, Antonini, P, Pongratz, P, Kern, P, Saraiva Da Cunha, J, Soriano-Arandes, A, Schunk, M, Suttorp, N, Hatz, C & Zoller, T 2015, 'Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: The TropNet severe malaria study', Clinical Infectious Diseases, vol. 61, no. 9, pp. 1441-1444. https://doi.org/10.1093/cid/civ575

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abstract = "Intravenous artesunate improves survival in severe malaria, but clinical trial data from nonendemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs quinine treatment. Artesunate reduced parasite clearance time and duration of intensive care unit and hospital treatment in European patients with imported severe malaria.",

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AU - Bartoloni, Alessandro

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AU - Saraiva Da Cunha, José

AU - Soriano-Arandes, Antoni

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Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: The TropNet severe malaria study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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