Intravenous glycerol-vitamin C (sodium salt) as osmotic agents to reduce intraocular pressure

Michele Virno, Massimo G. Bucci, Jose Pecori-Giraldi, Giampaolo Cantore

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The experimental and clinical results obtained with the intravenous use of vitamin C (sodium salt) as an agent for the osmotic reduction of intraocular pressure are presented. The method of its administration and some case reports are described. In a dosage of 0.4 to 1.0 gm/kg body weight intravenously, administered as a 20% solution at pH 7.2 to 7.4, vitamin C (sodium salt) induces marked ocular hypotony in approximately 60 to 90 minutes. Furthermore, vitamin C (sodium salt) has proved useful in completely eliminating the hematuria produced by the intravenous administration of glycerol. No evidence of hematuria after intravenous administration of 30% glycerol combined with 20% vitamin C (sodium salt) was found. The experimental and clinical results show that a combination of glycerol-sodium ascorbate is a highly effective intravenous osmotic method to produce a significant reduction in intraocular pressure.

Original languageEnglish
Pages (from-to)824-833
Number of pages10
JournalAmerican Journal of Ophthalmology
Issue number5
Publication statusPublished - Nov 1966

ASJC Scopus subject areas

  • Ophthalmology


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