TY - JOUR
T1 - Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy
AU - Plazzi, Giuseppe
AU - Poli, Francesca
AU - Franceschini, Christian
AU - Parmeggiani, Antonia
AU - Pirazzoli, Piero
AU - Bernardi, Filippo
AU - Mignot, Emmanuel
AU - Cicognani, Alessandro
AU - Montagna, Pasquale
PY - 2008/10
Y1 - 2008/10
N2 - We report on the outcome of intravenous high-dose immunoglobulin (IVIg) treatment in four children with narcolepsy and cataplexy, in whom the early diagnosis and the extreme disease severity were indications for this potentially efficacious therapy. One of four patients showed an objective and persistent improvement in clinical features during and after IVIg treatment. Our data partially support the recent report of the efficacy of IVIg treatment in early diagnosed narcolepsy with cataplexy and support the need for a controlled multicenter clinical trial on IVIg in narcolepsy.
AB - We report on the outcome of intravenous high-dose immunoglobulin (IVIg) treatment in four children with narcolepsy and cataplexy, in whom the early diagnosis and the extreme disease severity were indications for this potentially efficacious therapy. One of four patients showed an objective and persistent improvement in clinical features during and after IVIg treatment. Our data partially support the recent report of the efficacy of IVIg treatment in early diagnosed narcolepsy with cataplexy and support the need for a controlled multicenter clinical trial on IVIg in narcolepsy.
KW - Early treatment
KW - Intravenous immunoglobulins
KW - Narcolepsy with cataplexy
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U2 - 10.1007/s00415-008-0983-7
DO - 10.1007/s00415-008-0983-7
M3 - Article
C2 - 18769859
AN - SCOPUS:56349137577
VL - 255
SP - 1549
EP - 1554
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 10
ER -