Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy

Giuseppe Plazzi, Francesca Poli, Christian Franceschini, Antonia Parmeggiani, Piero Pirazzoli, Filippo Bernardi, Emmanuel Mignot, Alessandro Cicognani, Pasquale Montagna

Research output: Contribution to journalArticlepeer-review

Abstract

We report on the outcome of intravenous high-dose immunoglobulin (IVIg) treatment in four children with narcolepsy and cataplexy, in whom the early diagnosis and the extreme disease severity were indications for this potentially efficacious therapy. One of four patients showed an objective and persistent improvement in clinical features during and after IVIg treatment. Our data partially support the recent report of the efficacy of IVIg treatment in early diagnosed narcolepsy with cataplexy and support the need for a controlled multicenter clinical trial on IVIg in narcolepsy.

Original languageEnglish
Pages (from-to)1549-1554
Number of pages6
JournalJournal of Neurology
Volume255
Issue number10
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Early treatment
  • Intravenous immunoglobulins
  • Narcolepsy with cataplexy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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