Abstract
This review deals with the use of intravenous IVIg immunoglobulines in the treatment of chronic immune-mediated neuropathies: multifocal motor neuropathy, chronic inflammatory demyelinating polyneuropathy, neuropathies associated with monoclonal gammopathies. A particular attention is given to case series and trials which compare IVIg to other therapies, such as steroid treatment, immunosuppressors and plasma exchange. At present, clinical and instrumental data seem to indicate the shore term efficacy of IVIg in multifocal motor neuropathies, especially os early treatment. Further studies are need in order to prove its long term efficacy in this disease. Concerning chronic inflammatory demyelinating polyneuropathies, short term IVIg efficacy is comparable to that of plasma exchange and in the long term most patients need repeated treatments. Most patients respond to the initial therapy and the initial nonresponders usually improve with a second treatment modality.
Original language | English |
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Pages (from-to) | 93-97 |
Number of pages | 5 |
Journal | Multiple Sclerosis Journal |
Volume | 3 |
Issue number | 2 |
Publication status | Published - Apr 1997 |
Keywords
- Chronic inflammatory demyelinating polyradiculoneuropathy
- Immunoglobulin
- Intravenous gamma globulin
- Monoclonal gammopathy
- Multifocal motor neuropathy
- Plasma exchange
- Steroid treatment
- Treatment
ASJC Scopus subject areas
- Clinical Neurology