Intravenous immunoglobulin treatment in multifocal motor neuropathy and other chronic immune-mediated neuropathies

G. Comi, R. Nemni, S. Amadio, G. Galardi, L. Leocani

Research output: Contribution to journalArticlepeer-review

Abstract

This review deals with the use of intravenous IVIg immunoglobulines in the treatment of chronic immune-mediated neuropathies: multifocal motor neuropathy, chronic inflammatory demyelinating polyneuropathy, neuropathies associated with monoclonal gammopathies. A particular attention is given to case series and trials which compare IVIg to other therapies, such as steroid treatment, immunosuppressors and plasma exchange. At present, clinical and instrumental data seem to indicate the shore term efficacy of IVIg in multifocal motor neuropathies, especially os early treatment. Further studies are need in order to prove its long term efficacy in this disease. Concerning chronic inflammatory demyelinating polyneuropathies, short term IVIg efficacy is comparable to that of plasma exchange and in the long term most patients need repeated treatments. Most patients respond to the initial therapy and the initial nonresponders usually improve with a second treatment modality.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalMultiple Sclerosis Journal
Volume3
Issue number2
Publication statusPublished - Apr 1997

Keywords

  • Chronic inflammatory demyelinating polyradiculoneuropathy
  • Immunoglobulin
  • Intravenous gamma globulin
  • Monoclonal gammopathy
  • Multifocal motor neuropathy
  • Plasma exchange
  • Steroid treatment
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology

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