Intravenous methylprednisolone in minimal change nephrotic syndrome

C. Ponticelli, E. Imbasciati, N. Case, P. Zucchelli, L. Cagnoli, S. Pasquali

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Prednisone by mouth in large doses usually reverses minimal change nephrotic syndrome but there may be severe side effects, particularly in patients with frequent relapses. We therefore tried a new regiment beginning with three consecutive pulses of intravenous methylprednisolone and following these with prednisone by mouth in low doses (15-20 mg/kg). The urine became protein free in all our patients and a remission was reached even in frequent relapsers. Three patients with heavy proteinuria in relapse rapidly responded to further treatment with intravenous methylprednisolone. None of our patients suffered from hypercorticism or other side effects. These preliminary results seem to indicate that our regimen might be effective and well tolerated in most patients with lipoid nephrosis.

Original languageEnglish
Pages (from-to)685
Number of pages1
JournalBritish Medical Journal
Issue number6215
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Medicine(all)

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    Ponticelli, C., Imbasciati, E., Case, N., Zucchelli, P., Cagnoli, L., & Pasquali, S. (1980). Intravenous methylprednisolone in minimal change nephrotic syndrome. British Medical Journal, 280(6215), 685.