Intravenous methylprednisolone pulse therapy for children with epileptic encephalopathy

Maria Carmela Pera, Giovanna Randazzo, Silvia Masnada, Serena Donetti Dontin, Valentina De Giorgis, Umberto Balottin, Pierangelo Veggiotti

Research output: Contribution to journalArticlepeer-review


The aim of this retrospective study of children affect­ed by epileptic encephalopathy was to evaluate seizure frequency, electroencephalographic pattern and neuropsychological status, before and after intravenous methylprednisolone therapy. Eleven children with epileptic encephalopathy were administered one cycle of intravenous methylpred­nisolone (15-30 mg/kg/day for three consecutive days, once a month for four months) in addition to constant dosages of their regular antiepileptic drugs. The treatment resulted in statistically significant reductions of generalized slow spike-and-wave dis­charges (p

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalFunctional Neurology
Issue number3
Publication statusPublished - Jul 1 2015


  • Epileptic encephalopathy
  • Intravenous methylprednisolone
  • Refractory epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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