Intravenous methylprednisolone pulse therapy for children with epileptic encephalopathy

Maria Carmela Pera; Giovanna Randazzo; Silvia Masnada; Serena Donetti Dontin; Valentina De Giorgis; Umberto Balottin; Pierangelo Veggiotti

Intravenous methylprednisolone pulse therapy for children with epileptic encephalopathy

Maria Carmela Pera, Giovanna Randazzo, Silvia Masnada, Serena Donetti Dontin, Valentina De Giorgis, Umberto Balottin, Pierangelo Veggiotti

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this retrospective study of children affected by epileptic encephalopathy was to evaluate seizure frequency, electroencephalographic pattern and neuropsychological status, before and after intravenous methylprednisolone therapy. Eleven children with epileptic encephalopathy were administered one cycle of intravenous methylprednisolone (15-30 mg/kg/day for three consecutive days, once a month for four months) in addition to constant dosages of their regular antiepileptic drugs. The treatment resulted in statistically significant reductions of generalized slow spike-and-wave discharges (p

Original language	English
Pages (from-to)	173-179
Number of pages	7
Journal	Functional Neurology
Volume	30
Issue number	3
Publication status	Published - Jul 1 2015

Keywords

Epileptic encephalopathy
Intravenous methylprednisolone
Refractory epilepsy

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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Intravenous methylprednisolone pulse therapy for children with epileptic encephalopathy. / Pera, Maria Carmela; Randazzo, Giovanna; Masnada, Silvia; Dontin, Serena Donetti; De Giorgis, Valentina; Balottin, Umberto; Veggiotti, Pierangelo.

In: Functional Neurology, Vol. 30, No. 3, 01.07.2015, p. 173-179.

Research output: Contribution to journal › Article › peer-review

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