Intravenous methylprednisolone pulse therapy in essential mixed cryoglobulinemia nephropathy

A. de Vecchi, G. Montagnino, C. Pozzi, A. Tarantino, F. Locatelli, C. Ponticelli

Research output: Contribution to journalArticlepeer-review


In 15 patients with essential mixed cryoglobulinemia, 24 exacerbations of renal disease, characterized by an increase in plasma creatinine (13 episodes) and/or proteinuria (18 episodes), were treated by 3 intravenous pulses of methylprednisolone (1 g each), followed by oral prednisone (0.5 mg/kg/day). Plasma creatinine levels fell within a week (P <0.025), while a significant decrease in urinary protein excretion was observed only after one month (P <0.05). After therapy, plasma creatinine levels remained stable in 8/10 patients for 3 to 60 months. These beneficial results suggest that MP pulses may be useful in the treatment of cryoglobulinemic nephropathy.

Original languageEnglish
Pages (from-to)221-227
Number of pages7
JournalClinical Nephrology
Issue number5
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Nephrology


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