Intravenous morphine increases glucose utilization in the shell of the rat nucleus accumbens

Francesco Orzi, Francesca Passarelli, Maurizio La Riccia, Renato Di Grezia, Francesco E. Pontieri

Research output: Contribution to journalArticle

Abstract

The [14C]2-deoxyglucose method was applied to measure the effects of the acute intravenous administration of morphine sulphate (0.2-0.4 mg/kg) on cerebral glucose utilization in rats. Morphine produced dose-dependent increases of glucose metabolism in the shell of the nucleus accumbens, without affecting functional activity in any other brain area. These results provide further evidence for the preferential effects of intravenously abused substances in the shell of the nucleus accumbens.

Original languageEnglish
Pages (from-to)49-51
Number of pages3
JournalEuropean Journal of Pharmacology
Volume302
Issue number1-3
DOIs
Publication statusPublished - Apr 29 1996

Keywords

  • Deoxyglucose
  • Drug abuse
  • Morphine
  • Nucleus accumbens
  • Shell

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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