Intravenous nitroglycerin suppresses exercise-induced arrhythmias in patients with ischaemic heart disease: Implications for long-term treatment

A. Margonato, F. Bonetti, A. Mailhac, G. Vicedomini, D. Cianflone, S. L. Chierchia

Research output: Contribution to journalArticle


We studied 20 patients with ischaemic heart disease, who consistently developed complex ventricular arrhythmias during exercise testing. Treadmill exercise was performed twice, both during the placebo infusion and then during intravenous administration of nitroglycerin, titrated to reduce systolic blood pressure by 10 mmHg. Exercise duration in those administered placebo was 7.8 ± 1.7 and 7.9 ± 1.5 min, respectively (ns): angina developed in five patients and ischaemic ST changes in 10. In those administered nitroglycerin, exercise duration increased to 8.4 ± 2 min (P

Original languageEnglish
Pages (from-to)1278-1282
Number of pages5
JournalEuropean Heart Journal
Issue number12
Publication statusPublished - 1991



  • Exercise-induced arrhythmias
  • Ischaemic heart disease
  • Nitrates

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology

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