Intravescical electromotive drug administration of Epirubicin: An experimental study

L. Carmignani, M. Panizzutti, F. Verweij, F. Rocco, D. Cova, A. Rossignoli, E. Guido, F. Acocella, G. Vanosi, F. Addis

Research output: Contribution to journalArticlepeer-review

Abstract

Intravescical instillation of Epirubicin after endoscopic resection for bladder tumors has proved its value in several studies, and has become a common practice. EMDA (Electromotive Drug Administration) consists of an active transport of ionic drugs into tissues by electricity. This particular technique of drug delivery through tissues was tested using Epirubicin. The main objectives of this study were: 1) the development of an experimental model to ascertain such a method of uptake; 2) the evaluation of drug concentration within bladder lesions after passive diffusion or EMDA. Six female Landrace pigs of 30 Kg. weight underwent anaesthesia by Isofluoran and Oxygen. A small epicystotomy was made just above the bladder neck. Then a biopsy of the posterior bladder wall was performed and was followed by electrocoagulation. An electrode-containing catheter was inserted through the cystotomy situated so as to lie in the approximate center of the bladder. In Group I (2 pigs) 50 ml of 0.45% saline containing 50 mg of Epirubicin was instilled and left in the bladder 1 hr. In Group II (2 pigs) 50 ml of 0.45% saline and 50 mg Epirubicin was instilled, and an electric current of 20 mA was passed through the electrode after closure of the abdominal wall. The same 20 mA current was applied in both Group III pigs, in which a solution of 100 ml 0.45% saline and 50 mg Epirubicin was instilled. Electricity was applied during a 15 min period in both Group II and III pigs. After 15 minutes the bladders were drained and excised. Tissue samples were taken from both the endoscopic lesion site and from the intact wall. In addition plasma samples were taken during instillation and after 15, 30 and 60 minutes. Epirubicin was shown in a higher concentration in those areas with lesions. It seems not to be the ideal drug for intravescical EMDA.

Original languageEnglish
Pages (from-to)57-59
Number of pages3
JournalActa Urologica Italica
Volume11
Issue number1
Publication statusPublished - 1997

Keywords

  • bladder neoplasm
  • electromotive drug administration
  • epirubicin

ASJC Scopus subject areas

  • Urology

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