Intravesical capsaicin for treatment of severe bladder pain

A randomized placebo controlled study

M. Lazzeri, P. Beneforti, G. Benaim, C. A. Maggi, A. Lecci, D. Turini

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Purpose: Present therapeutic approaches to control bladder pain are clinically and scientifically unsatisfactory, and pain in the lower urinary tract remains a challenge even to the skilled urologist. A randomized placebo controlled study was done to evaluate intravesical capsaicin for severe bladder pain. Followup was 6 months. Materials and Methods: A total of 36 patients was prospectively randomized into those receiving 10 μM. intravesical capsaicin twice weekly for 1 month (group 1) or placebo (group 2). All patients had pelvic pain for at least 6 months, and had no urinary tract infection within the last 3 months, functional disorders of the lower urinary tract, or other vesical or urethral pathology. Pretreatment voiding pattern and pain score were recorded. Patients were evaluated immediately at the end of treatment (primary end point) and 6 months later (secondary end point). Results: Both groups were adequately homogeneous with regard to age, sex ratio, duration of disease, voiding pattern and pain score. At both end points group 1 had significant improvement in frequency and nocturia but no improvement in urgency. No change was noted in group 2. A significant decrease in pain score was found in group 1 at the primary (mean plus or minus standard deviation 3.22 ± 0.42, p

Original languageEnglish
Pages (from-to)947-952
Number of pages6
JournalJournal of Urology
Volume156
Issue number3
Publication statusPublished - Sep 1996

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Capsaicin
Urinary Bladder
Placebos
Pain
Urinary Tract
Therapeutics
Nocturia
Pelvic Pain
Sex Ratio
Urinary Tract Infections
Pathology

Keywords

  • bladder diseases
  • capsaicin
  • pain

ASJC Scopus subject areas

  • Urology

Cite this

Lazzeri, M., Beneforti, P., Benaim, G., Maggi, C. A., Lecci, A., & Turini, D. (1996). Intravesical capsaicin for treatment of severe bladder pain: A randomized placebo controlled study. Journal of Urology, 156(3), 947-952.

Intravesical capsaicin for treatment of severe bladder pain : A randomized placebo controlled study. / Lazzeri, M.; Beneforti, P.; Benaim, G.; Maggi, C. A.; Lecci, A.; Turini, D.

In: Journal of Urology, Vol. 156, No. 3, 09.1996, p. 947-952.

Research output: Contribution to journalArticle

Lazzeri, M, Beneforti, P, Benaim, G, Maggi, CA, Lecci, A & Turini, D 1996, 'Intravesical capsaicin for treatment of severe bladder pain: A randomized placebo controlled study', Journal of Urology, vol. 156, no. 3, pp. 947-952.
Lazzeri, M. ; Beneforti, P. ; Benaim, G. ; Maggi, C. A. ; Lecci, A. ; Turini, D. / Intravesical capsaicin for treatment of severe bladder pain : A randomized placebo controlled study. In: Journal of Urology. 1996 ; Vol. 156, No. 3. pp. 947-952.
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