Intravesical capsaicin versus resiniferatoxin in patients with detrusor hyperreflexia: A prospective randomized study

Antonella Giannantoni, Savino M. Di Stasi, Robert L. Stephen, Pierluigi Navarra, Giorgio Scivoletto, Ettore Mearini, Massimo Porena

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Capsaicin and resiniferatoxin (Sigma Chemical Co., St. Louis, Missouri) administered intravesically are attractive options for treating detrusor hyperreflexia. Because the 2 agents differ in chemical structure and relative potency, possible differences in their clinical and urodynamic effects were investigated in this prospective comparative study. Materials and Methods: A group of 24 spinal cord injured patients with refractory detrusor hyperreflexia were randomly assigned to receive a single dose of 2 mM. capsaicin in 30 ml. ethanol plus 70 ml. 0.9% sodium chloride or 100 nM. resiniferatoxin in 100 ml. 0.9% sodium chloride. Dwell time was 40 minutes with urodynamic monitoring. Urodynamics were performed at baseline before treatment, and after followups of 30 and 60 days. The frequency of daily catheterizations, incontinence episodes and side effects was recorded. Results: There was no significant urodynamic or clinical improvement in the capsaicin arm at 30 and 60 days of followup. In the resiniferatoxin arm the mean uninhibited detrusor contraction threshold plus or minus standard deviation increased from 176 ± 54 to 250 ± 107 ml. at 30 days (p

Original languageEnglish
Pages (from-to)1710-1714
Number of pages5
JournalJournal of Urology
Volume167
Issue number4 I
Publication statusPublished - 2002

Keywords

  • Bladder
  • Capsaicin
  • Spinal cord injuries
  • Urinary incontinence

ASJC Scopus subject areas

  • Urology

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