Intravesical hyaluronic acid and chondroitin sulphate improve symptoms and quality of life in patients with late radiation tissue cystitis: An investigative pilot study

M. L. Sommariva, M. Lazzeri, A. Abrate, G. Guazzoni, S. Sandri, F. Montorsi

Research output: Contribution to journalArticlepeer-review

Abstract

Intravesical hyaluronic acid (HA) and chondroitin sulphate (CS) instillation are effective for urinary tract infections (UTIs) and bladder pain syndrome. This study aimed to evaluate the tolerability, safety and efficacy of intravesical HA and CS instillation in patients with late radiation tissue cystitis (LRTC). In this pilot study, tolerability was reported as discontinuation or deviation of the protocol, safety as general or local side effects, efficacy as improvement of bladder capacity and frequency, quality of life (QoL) through the European Quality of Life 5-Dimensions (EQ-5D) (details at http://www.controlled-trials. com/ISRCTN37534393). Thirty-two patients with LRTC were enrolled. Twenty-seven patients (84.8%) received a mean of 12.2±0.3 months of instillation therapy. Only two patients (6.2%) developed a urinary tract infection from instillation, which required antibiotic treatment, nevertheless not compromising the therapy schedule. No male patient developed a urethral stricture. Intravesical instillation was associated with a significant increase (>50%) of bladder capacity from baseline (66.9ml) both at 3 months (101.9 ml; p

Original languageEnglish
Pages (from-to)177-185
Number of pages9
JournalEuropean Journal of Inflammation
Volume12
Issue number1
Publication statusPublished - 2014

Keywords

  • Chondroitin sulphate
  • Hyaluronic acid
  • Radiation cystitis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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