Intravitreal bevacizumab for retinal neovascularizations associated with myelinated nerve fibers

Maurizio Battaglia Parodi, Umberto De Benedetto, Stefano Vergallo, Karl Anders Knutsson, Francesco Bandello, Paolo Lanzetta, Pierluigi Iacono

Research output: Contribution to journalArticle

Abstract

Purpose: To report the effects of intravitreal bevacizumab injection (IVBI) in a patient affected by retinal neovascularizations (RNVs) associated with myelinated nerve fibers (MNF) and complicated by vitreous hemorrhage. Methods: A 23-year-old female was referred because of sudden visual acuity deterioration in the left eye. Nine years earlier, the subject underwent retinal laser photocoagulation for recurrent vitreous hemorrhages related to the development of RNV associated with MNF. The ophthalmological evaluation revealed a new recurrence of vitreous hemorrhage associated with fluorescein leakage from RNV. After careful discussion, the patient underwent IVBI. Results: One month after the injection, the best corrected visual acuity (BCVA) improved from 20/400 to 20/100, with a vitreous hemorrhage resolution, and cessation of fluorescein leakage. Over the 24-month follow-up, 2 additional IVBIs were administered due to further vitreous hemorrhage associated with fluorescein leakage from RNV, achieving a final BCVA of 20/80. Conclusions: IVBI may temporarily counteract the vascular hyperpermeability typical of RNV associated with MNF, leading to the cessation of fluorescein leakage, but does not result in RNV regression.

Original languageEnglish
Pages (from-to)442-443
Number of pages2
JournalJournal of Ocular Pharmacology and Therapeutics
Volume29
Issue number4
DOIs
Publication statusPublished - May 1 2013

Fingerprint

Retinal Neovascularization
Myelinated Nerve Fibers
Vitreous Hemorrhage
Fluorescein
Intravitreal Injections
Visual Acuity
Light Coagulation
Blood Vessels
Bevacizumab
Lasers
Recurrence
Injections

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Ophthalmology
  • Pharmacology

Cite this

Intravitreal bevacizumab for retinal neovascularizations associated with myelinated nerve fibers. / Parodi, Maurizio Battaglia; De Benedetto, Umberto; Vergallo, Stefano; Knutsson, Karl Anders; Bandello, Francesco; Lanzetta, Paolo; Iacono, Pierluigi.

In: Journal of Ocular Pharmacology and Therapeutics, Vol. 29, No. 4, 01.05.2013, p. 442-443.

Research output: Contribution to journalArticle

Parodi, Maurizio Battaglia ; De Benedetto, Umberto ; Vergallo, Stefano ; Knutsson, Karl Anders ; Bandello, Francesco ; Lanzetta, Paolo ; Iacono, Pierluigi. / Intravitreal bevacizumab for retinal neovascularizations associated with myelinated nerve fibers. In: Journal of Ocular Pharmacology and Therapeutics. 2013 ; Vol. 29, No. 4. pp. 442-443.
@article{8930ad3647074258a54ece34bdadd532,
title = "Intravitreal bevacizumab for retinal neovascularizations associated with myelinated nerve fibers",
abstract = "Purpose: To report the effects of intravitreal bevacizumab injection (IVBI) in a patient affected by retinal neovascularizations (RNVs) associated with myelinated nerve fibers (MNF) and complicated by vitreous hemorrhage. Methods: A 23-year-old female was referred because of sudden visual acuity deterioration in the left eye. Nine years earlier, the subject underwent retinal laser photocoagulation for recurrent vitreous hemorrhages related to the development of RNV associated with MNF. The ophthalmological evaluation revealed a new recurrence of vitreous hemorrhage associated with fluorescein leakage from RNV. After careful discussion, the patient underwent IVBI. Results: One month after the injection, the best corrected visual acuity (BCVA) improved from 20/400 to 20/100, with a vitreous hemorrhage resolution, and cessation of fluorescein leakage. Over the 24-month follow-up, 2 additional IVBIs were administered due to further vitreous hemorrhage associated with fluorescein leakage from RNV, achieving a final BCVA of 20/80. Conclusions: IVBI may temporarily counteract the vascular hyperpermeability typical of RNV associated with MNF, leading to the cessation of fluorescein leakage, but does not result in RNV regression.",
author = "Parodi, {Maurizio Battaglia} and {De Benedetto}, Umberto and Stefano Vergallo and Knutsson, {Karl Anders} and Francesco Bandello and Paolo Lanzetta and Pierluigi Iacono",
year = "2013",
month = "5",
day = "1",
doi = "10.1089/jop.2012.0094",
language = "English",
volume = "29",
pages = "442--443",
journal = "Journal of Ocular Pharmacology and Therapeutics",
issn = "1080-7683",
publisher = "Mary Ann Liebert Inc.",
number = "4",

}

TY - JOUR

T1 - Intravitreal bevacizumab for retinal neovascularizations associated with myelinated nerve fibers

AU - Parodi, Maurizio Battaglia

AU - De Benedetto, Umberto

AU - Vergallo, Stefano

AU - Knutsson, Karl Anders

AU - Bandello, Francesco

AU - Lanzetta, Paolo

AU - Iacono, Pierluigi

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Purpose: To report the effects of intravitreal bevacizumab injection (IVBI) in a patient affected by retinal neovascularizations (RNVs) associated with myelinated nerve fibers (MNF) and complicated by vitreous hemorrhage. Methods: A 23-year-old female was referred because of sudden visual acuity deterioration in the left eye. Nine years earlier, the subject underwent retinal laser photocoagulation for recurrent vitreous hemorrhages related to the development of RNV associated with MNF. The ophthalmological evaluation revealed a new recurrence of vitreous hemorrhage associated with fluorescein leakage from RNV. After careful discussion, the patient underwent IVBI. Results: One month after the injection, the best corrected visual acuity (BCVA) improved from 20/400 to 20/100, with a vitreous hemorrhage resolution, and cessation of fluorescein leakage. Over the 24-month follow-up, 2 additional IVBIs were administered due to further vitreous hemorrhage associated with fluorescein leakage from RNV, achieving a final BCVA of 20/80. Conclusions: IVBI may temporarily counteract the vascular hyperpermeability typical of RNV associated with MNF, leading to the cessation of fluorescein leakage, but does not result in RNV regression.

AB - Purpose: To report the effects of intravitreal bevacizumab injection (IVBI) in a patient affected by retinal neovascularizations (RNVs) associated with myelinated nerve fibers (MNF) and complicated by vitreous hemorrhage. Methods: A 23-year-old female was referred because of sudden visual acuity deterioration in the left eye. Nine years earlier, the subject underwent retinal laser photocoagulation for recurrent vitreous hemorrhages related to the development of RNV associated with MNF. The ophthalmological evaluation revealed a new recurrence of vitreous hemorrhage associated with fluorescein leakage from RNV. After careful discussion, the patient underwent IVBI. Results: One month after the injection, the best corrected visual acuity (BCVA) improved from 20/400 to 20/100, with a vitreous hemorrhage resolution, and cessation of fluorescein leakage. Over the 24-month follow-up, 2 additional IVBIs were administered due to further vitreous hemorrhage associated with fluorescein leakage from RNV, achieving a final BCVA of 20/80. Conclusions: IVBI may temporarily counteract the vascular hyperpermeability typical of RNV associated with MNF, leading to the cessation of fluorescein leakage, but does not result in RNV regression.

UR - http://www.scopus.com/inward/record.url?scp=84880560518&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880560518&partnerID=8YFLogxK

U2 - 10.1089/jop.2012.0094

DO - 10.1089/jop.2012.0094

M3 - Article

VL - 29

SP - 442

EP - 443

JO - Journal of Ocular Pharmacology and Therapeutics

JF - Journal of Ocular Pharmacology and Therapeutics

SN - 1080-7683

IS - 4

ER -