Intravitreal bevacizumab versus low-fluence photodynamic therapy for treatment of chronic central serous chorioretinopathy

Francesco Semeraro, Mario R. Romano, Paola Danzi, Francesco Morescalchi, Ciro Costagliola

Research output: Contribution to journalArticlepeer-review


Purpose: To report the effectiveness and safety of intravitreal bevacizumab injection (IVB) compared with lowfluence photodynamic therapy (L-PDT) in eyes with chronic central serous chorioretinopathy (CSC). Methods: This was a prospective comparative interventional study of 22 patients affected by chronic CSC. Patients were randomly assigned to group 1 (12 patients treated with 1.25 mg IVB) and group 2 (10 patients treated with L-PDT). In group 2, PDT with verteporfin was delivered at low fluence (300 mW/cm2 for 83 s, 25 J/cm2). Follow-up visits were scheduled at 1, 3, 6, and 9 months. Results: The improvement in visual acuity was greater in group 1 than in group 2, although the difference was not statistically significant (P = 0.59). The mean change in central point thickness over 9 months from baseline was 127 μm (SD 36) in group 1 and 114 μm (SD 42) in group 2. After the first injection, retreatments were given if recurrence was noted, with an average of 3.0 ± 1 injections in group 1 and 1.6 ± 0.6 treatments with L-PDT in group 2. The difference between retreatment in the 2 groups was not statistically significant (P = 0.45). Conclusions: Based on the results obtained after 9 months of follow-up, our study provides evidence that IVB may be a treatment option for chronic CSC.

Original languageEnglish
Pages (from-to)608-612
Number of pages5
JournalJapanese Journal of Ophthalmology
Issue number6
Publication statusPublished - Nov 2012


  • Anti VEGF therapy
  • Central serous chorioretinopathy
  • Intravitreal bevacizumab
  • Retinal pigment epithelium detachment

ASJC Scopus subject areas

  • Ophthalmology


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