Intravitreal dexamethasone implant in patients with persistent diabetic macular edema

Ilaria Zucchiatti, Rosangela Lattanzio, Giuseppe Querques, Lea Querques, Claudia Del Turco, Maria Lucia Cascavilla, Francesco Bandello

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate the effects of a single injection of Ozurdex over 6 months in eyes with persistent diabetic macular edema (DME). Methods: In this retrospective interventional study, 9 patients with decreased visual acuity, as a result of persistent DME, received Ozurdex (intravitreal dexamethasone implant 0.7 mg). Main outcome measures included changes in best-corrected visual acuity (BCVA) and central retinal thickness (CRT). Results: Nine eyes of 9 patients (5 males, 4 females; mean age 58 years) were included in the analysis. The mean duration of DME was 49.9 months (range 24-85). All patients had undergone previous treatments for DME (intravitreal injection of anti-vascular endothelial growth factor, steroids or laser photocoagulation) before entering the study. At baseline, the mean BCVA was 0.74 ± 0.33 logMAR, and the mean CRT was 502 ± 222.16 μm. The mean BCVA was unchanged on the third day (0.74 ± 0.38 logMAR, p = 0.5), improved to 0.62 ± 0.32 logMAR (p = 0.02), 0.59 ± 0.26 logMAR (p = 0.02) and 0.63 ± 0.38 logMAR (p = 0.6) after the first, third and fourth months, respectively, and decreased again to 0.73 ± 0.35 logMAR (p = 0.4) at 6 months. The mean CRT improved to 397 ± 115.31 μm (p = 0.17), 271 ± 99.97 μm (p = 0.007), 325 ± 133.05 μm (p = 0.03) and 462 ± 176.48 μm (p = 0.36) on the third day and after 1, 3 and 4 months of follow-up and then increased again to 537 ± 265.42 μm (p = 0.33) at 6 months. Eight patients needed retreatments in the sixth month. One eye developed a transient intraocular pressure (IOP) increase 1 month after injection, which was successfully managed with topical IOP-lowering medication. Conclusion: In eyes with persistent DME, Ozurdex produces improvement in BCVA and CRT as soon as the first days after the injection. Such improvement is maintained until the fourth month.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalOphthalmologica
Volume228
Issue number2
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Diabetes
  • Macular edema
  • Optical coherence tomography
  • Ozurdex
  • Retinopathy

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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