Intravitreal dexamethasone implant in radiation-induced macular oedema.

L Frizziero, R Parrozzani, S Trainiti , E Pilotto , Giacomo Miglionico, Serena Pulze, Edoardo Midena

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Abstract

AIMS: To evaluate the efficacy and duration of activity of a single intravitreal dexamethasone implant in patients affected by radiation maculopathy. METHODS: Thirteen consecutive eyes of 13 patients affected by radiation maculopathy secondary to eye irradiation for a primary uveal melanoma (Iodine-125 brachytherapy) and treated with a single intravitreal 0.7 mg dexamethasone implant were retrospectively evaluated. Each patient underwent full ophthalmological examination, including fluorescein angiography and spectral domain optical coherence tomography (SD-OCT), even in en-face modality. Follow-up was performed monthly over a 6-month period. RESULTS: At preinjection visit, the median central subfield thickness (CST) by SD-OCT was 407 µm (IQR, 357-524 µm) and the median best-corrected visual acuity (BCVA) was 61 ETDRS score (IQR, 54-67). The median gain of ETDRS letter at 1 month was 6.5 (IQR, 4-15) (p<0.01). The median CST showed a reduction of 120 µm (IQR, 62-134) (p<0.01). Further CST reduction was reported at 2 months' follow-up, with CST stabilisation at 3 months and maintenance of BCVA. At 4, 5 and 6 months' follow-up, all patients presented progressive retinal thickening (p<0.01) and BCVA reduction (p<0.01). No side effects were documented. CONCLUSION: Intravitreal dexamethasone implant reduces macular oedema secondary to radiation maculopathy and also improved visual acuity in a consistent proportion of patients. Signs of macular oedema recurrence may be detected at a median of 4 months after injection. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly grante
Original languageEnglish
Pages (from-to)1693-1703
Number of pages11
JournalBritish Journal of Ophthalmology
Volume101
Issue number12
Publication statusPublished - Dec 2017

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Frizziero, L., Parrozzani, R., Trainiti , S., Pilotto , E., Miglionico, G., Pulze, S., & Midena, E. (2017). Intravitreal dexamethasone implant in radiation-induced macular oedema. British Journal of Ophthalmology, 101(12), 1693-1703.