Intravitreal ranibizumab for naive extrafoveal choroidal neovascularization secondary to age-related macular degeneration

Maurizio Parodi, Pierluigi Iacono, Carlo Spina, Lorenzo Iuliano, Giuseppe Giudice, Ugo Introini, Francesco Bandello

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE:: To investigate the effect of intravitreal ranibizumab on extrafoveal choroidal neovascularization secondary to age-related macular degeneration. METHODS:: Eighteen eyes affected by extrafoveal choroidal neovascularization secondary to age-related macular degeneration were prospectively enrolled in this study. After an initial intravitreal ranibizumab, all patients were reevaluated monthly over 12 months of follow-up. Further retreatments were performed on a pro re nata basis, depending on detection of any type of fluid on optical coherence tomography and/or the presence of leakage on fluorescein angiography. Primary outcome measures were mean changes in best-corrected visual acuity and the proportion of eyes gaining at least 15 letters (3 Early Treatment Diabetic Retinopathy Study [ETDRS] lines) at the end of the follow-up. Secondary outcome measures were central macular thickness variations and changes in choroidal neovascularization size. RESULTS:: Mean best-corrected visual acuity presented a significant improvement during the follow-up period, being 0.3 ± 0.2 logMAR at baseline and 0.2 ± 0.2 logMAR at the 12-month examination (P < 0.001). An improvement of at least 3 EDTRS lines was achieved by 6 eyes (33.3%), whereas 6 patients (33.3%) gained 1 to 2 lines. The mean central macular thickness at baseline was 314 ± 87 μm, changing to 268 ± 65 μm at the 12-month examination (P = 0.003). The mean lesion size was 1.4 ± 1.4 mm and remained stable throughout the follow-up, being 1.8 ± 2.9 mm at 12 months (P = 0.64). CONCLUSION:: Intravitreal ranibizumab administered after a pro re nata regimen with monthly evaluation is a beneficial approach for the management of extrafoveal choroidal neovascularization secondary to age-related macular degeneration over 12 months of follow-up. Further studies are warranted to confirm our preliminary results.

Original languageEnglish
Pages (from-to)2167-2170
Number of pages4
JournalRetina
Volume34
Issue number11
DOIs
Publication statusPublished - Nov 12 2014

Keywords

  • age-related macular degeneration
  • extrafoveal choroidal neovascularization
  • ranibizumab

ASJC Scopus subject areas

  • Medicine(all)
  • Ophthalmology

Fingerprint Dive into the research topics of 'Intravitreal ranibizumab for naive extrafoveal choroidal neovascularization secondary to age-related macular degeneration'. Together they form a unique fingerprint.

Cite this