Intrinsic damage to the major white matter tracts in patients with different clinical phenotypes of multiple sclerosis: A voxelwise diffusion-tensor MR study

Paolo Preziosa, Maria A. Rocca, Sarlota Mesaros, Elisabetta Pagani, Tatjana Stosic-Opincal, Katarina Kacar, Martina Absinta, Domenico Caputo, Jelena Drulovic, Giancarlo Comi, Massimo Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To apply voxelwise analysis of diffusion-tensor (DT) magnetic resonance (MR) tractography and T2-weighted MR lesion measurements to characterize intrinsic damage to the brain white matter (WM) tracts and the relation of this damage to the presence and location of focal lesions among the main clinical phenotypes of multiple sclerosis (MS). Materials and Methods: The study was conducted with institutional review board approval. Written informed consent was obtained from each participant. Brain dual-echo and DT MR images were obtained in 172 patients with MS (22 [13%] with clinically isolated syndromes [CIS] suggestive of MS, 51 [30%] with relapsing-remitting [RR] MS, 44 [26%] with secondary progressive MS, 20 [12%] with benign MS, 35 [20%] with primary progressive MS) and 46 healthy control subjects. Probability maps of the major brain WM tracts were produced. Between-group comparisons were assessed by using analysis of covariance. Results: Compared with the healthy control subjects, the patients with CIS had significantly increased (P

Original languageEnglish
Pages (from-to)541-550
Number of pages10
JournalRadiology
Volume260
Issue number2
DOIs
Publication statusPublished - Aug 2011

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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