TY - JOUR
T1 - Intrinsic epileptogenicity of gangliogliomas may be independent from co-occurring focal cortical dysplasia
AU - Barba, Carmen
AU - Coras, Roland
AU - Giordano, Flavio
AU - Buccoliero, Anna Maria
AU - Genitori, Lorenzo
AU - Blümcke, Ingmar
AU - Guerrini, Renzo
PY - 2011/11
Y1 - 2011/11
N2 - Gangliogliomas are a frequent cause of drug-resistant epilepsies in children. It remains unknown, however, whether gangliogliomas are intrinsically epileptogenic or if associated lesions contribute to their high epileptogenicity, i.e. associated focal cortical dysplasia (FCD). We report on a child operated twice for drug-resistant focal seizures symptomatic of a right temporal lobe lesion. Histological examination of the first, incomplete lesionectomy revealed tumor-associated FCD Type IIIb. The child was not seizure-free, and surface as well as intracerebral recordings were obtained during a second presurgical assessment. Histopathological examination of the second operation revealed a ganglioglioma. Intralesional EEG recordings from the ganglioglioma documented rhythmic bursts of fast activity suggesting that the high epileptogenicity of gangliogliomas is related to intrinsic epileptogenic activity.
AB - Gangliogliomas are a frequent cause of drug-resistant epilepsies in children. It remains unknown, however, whether gangliogliomas are intrinsically epileptogenic or if associated lesions contribute to their high epileptogenicity, i.e. associated focal cortical dysplasia (FCD). We report on a child operated twice for drug-resistant focal seizures symptomatic of a right temporal lobe lesion. Histological examination of the first, incomplete lesionectomy revealed tumor-associated FCD Type IIIb. The child was not seizure-free, and surface as well as intracerebral recordings were obtained during a second presurgical assessment. Histopathological examination of the second operation revealed a ganglioglioma. Intralesional EEG recordings from the ganglioglioma documented rhythmic bursts of fast activity suggesting that the high epileptogenicity of gangliogliomas is related to intrinsic epileptogenic activity.
KW - Epilepsy surgery
KW - Epileptogenicity
KW - Focal cortical dysplasia
KW - Ganglioglioma
KW - Intracranial EEG
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U2 - 10.1016/j.eplepsyres.2011.07.004
DO - 10.1016/j.eplepsyres.2011.07.004
M3 - Article
C2 - 21831599
AN - SCOPUS:81055157930
VL - 97
SP - 208
EP - 213
JO - Epilepsy Research
JF - Epilepsy Research
SN - 0920-1211
IS - 1-2
ER -