Intrinsic epileptogenicity of gangliogliomas may be independent from co-occurring focal cortical dysplasia

Carmen Barba, Roland Coras, Flavio Giordano, Anna Maria Buccoliero, Lorenzo Genitori, Ingmar Blümcke, Renzo Guerrini

Research output: Contribution to journalArticle

Abstract

Gangliogliomas are a frequent cause of drug-resistant epilepsies in children. It remains unknown, however, whether gangliogliomas are intrinsically epileptogenic or if associated lesions contribute to their high epileptogenicity, i.e. associated focal cortical dysplasia (FCD). We report on a child operated twice for drug-resistant focal seizures symptomatic of a right temporal lobe lesion. Histological examination of the first, incomplete lesionectomy revealed tumor-associated FCD Type IIIb. The child was not seizure-free, and surface as well as intracerebral recordings were obtained during a second presurgical assessment. Histopathological examination of the second operation revealed a ganglioglioma. Intralesional EEG recordings from the ganglioglioma documented rhythmic bursts of fast activity suggesting that the high epileptogenicity of gangliogliomas is related to intrinsic epileptogenic activity.

Original languageEnglish
Pages (from-to)208-213
Number of pages6
JournalEpilepsy Research
Volume97
Issue number1-2
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Epilepsy surgery
  • Epileptogenicity
  • Focal cortical dysplasia
  • Ganglioglioma
  • Intracranial EEG

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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