Intrinsic functional connectivity differentiates minimally conscious from unresponsive patients

Athena Demertzi, Georgios Antonopoulos, Lizette Heine, Henning U. Voss, Julia Sophia Crone, Carlo De Los Angeles, Mohamed Ali Bahri, Carol Di Perri, Audrey Vanhaudenhuyse, Vanessa Charland-Verville, Martin Kronbichler, Eugen Trinka, Christophe Phillips, Francisco Gomez, Luaba Tshibanda, Andrea Soddu, Nicholas D. Schiff, Susan Whitfield-Gabrieli, Steven Laureys

Research output: Contribution to journalArticlepeer-review

Abstract

Despite advances in resting state functional magnetic resonance imaging investigations, clinicians remain with the challenge of how to implement this paradigm on an individualized basis. Here, we assessed the clinical relevance of resting state functional magnetic resonance imaging acquisitions in patients with disorders of consciousness by means of a systems-level approach. Three clinical centres collected data from 73 patients in minimally conscious state, vegetative state/unresponsive wakefulness syndrome and coma. The main analysis was performed on the data set coming from one centre (Liège) including 51 patients (26 minimally conscious state, 19 vegetative state/unresponsive wakefulness syndrome, six coma; 15 females; mean age 49 ± 18 years, range 11-87; 16 traumatic, 32 non-traumatic of which 13 anoxic, three mixed; 35 patients assessed >1 month post-insult) for whom the clinical diagnosis with the Coma Recovery Scale-Revised was congruent with positron emission tomography scanning. Group-level functional connectivity was investigated for the default mode, frontoparietal, salience, auditory, sensorimotor and visual networks using a multiple-seed correlation approach. Between-group inferential statistics and machine learning were used to identify each network's capacity to discriminate between patients in minimally conscious state and vegetative state/unresponsive wakefulness syndrome. Data collected from 22 patients scanned in two other centres (Salzburg: 10 minimally conscious state, five vegetative state/unresponsive wakefulness syndrome; New York: five minimally conscious state, one vegetative state/unresponsive wakefulness syndrome, one emerged from minimally conscious state) were used to validate the classification with the selected features. Coma Recovery Scale-Revised total scores correlated with key regions of each network reflecting their involvement in consciousness-related processes. All networks had a high discriminative capacity (>80%) for separating patients in a minimally conscious state and vegetative state/unresponsive wakefulness syndrome. Among them, the auditory network was ranked the most highly. The regions of the auditory network which were more functionally connected in patients in minimally conscious state compared to vegetative state/unresponsive wakefulness syndrome encompassed bilateral auditory and visual cortices. Connectivity values in these three regions discriminated congruently 20 of 22 independently assessed patients. Our findings point to the significance of preserved abilities for multisensory integration and top-down processing in minimal consciousness seemingly supported by auditory-visual crossmodal connectivity, and promote the clinical utility of the resting paradigm for single-patient diagnostics.

Original languageEnglish
Pages (from-to)2619-2631
Number of pages13
JournalBrain
Volume138
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • anoxia
  • consciousness
  • resting state connectivity
  • sensory systems
  • traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Medicine(all)

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