TY - JOUR
T1 - Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite
AU - Tampieri, Anna
AU - D'Alessandro, Teresa
AU - Sandri, Monica
AU - Sprio, Simone
AU - Landi, Elena
AU - Bertinetti, Luca
AU - Panseri, Silvia
AU - Pepponi, Giancarlo
AU - Goettlicher, Joerg
AU - Bañobre-López, Manuel
AU - Rivas, Jose
PY - 2012/2
Y1 - 2012/2
N2 - The use of magnetic activation has been proposed to answer the growing need for assisted bone and vascular remodeling during template/scaffold regeneration. With this in mind, a synthesis procedure was developed to prepare bioactive (Fe 2+/Fe 3+)-doped hydroxyapatite (Fe-HA), endowed with superparamagnetic-like properties. This new class of magnetic hydroxyapatites can be potentially employed to develop new magnetic ceramic scaffolds with enhanced regenerative properties for bone surgery; in addition, magnetic Fe-HA can find application in anticancer therapies, to replace the widely used magnetic iron oxide nanoparticles, whose long-term cytotoxicity was recently found to reach harmful levels. An extensive physicochemical, microstructural and magnetic characterization was performed on the obtained Fe-HA powders, and demonstrated that the simultaneous addition of Fe 2+ and Fe 3+ ions during apatite nucleation under controlled synthesis conditions induces intrinsic magnetization in the final product, minimizing the formation of magnetite as secondary phase. This result potentially opens new perspectives for biodevices aimed at bone regeneration and for anti-cancer therapies based on hyperthermia.
AB - The use of magnetic activation has been proposed to answer the growing need for assisted bone and vascular remodeling during template/scaffold regeneration. With this in mind, a synthesis procedure was developed to prepare bioactive (Fe 2+/Fe 3+)-doped hydroxyapatite (Fe-HA), endowed with superparamagnetic-like properties. This new class of magnetic hydroxyapatites can be potentially employed to develop new magnetic ceramic scaffolds with enhanced regenerative properties for bone surgery; in addition, magnetic Fe-HA can find application in anticancer therapies, to replace the widely used magnetic iron oxide nanoparticles, whose long-term cytotoxicity was recently found to reach harmful levels. An extensive physicochemical, microstructural and magnetic characterization was performed on the obtained Fe-HA powders, and demonstrated that the simultaneous addition of Fe 2+ and Fe 3+ ions during apatite nucleation under controlled synthesis conditions induces intrinsic magnetization in the final product, minimizing the formation of magnetite as secondary phase. This result potentially opens new perspectives for biodevices aimed at bone regeneration and for anti-cancer therapies based on hyperthermia.
KW - Bone regeneration
KW - Hydroxyapatite
KW - Hyperthermia
KW - Magnetic properties
KW - Superparamagnetism
UR - http://www.scopus.com/inward/record.url?scp=84855418621&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855418621&partnerID=8YFLogxK
U2 - 10.1016/j.actbio.2011.09.032
DO - 10.1016/j.actbio.2011.09.032
M3 - Article
C2 - 22005331
AN - SCOPUS:84855418621
VL - 8
SP - 843
EP - 851
JO - Acta Biomaterialia
JF - Acta Biomaterialia
SN - 1742-7061
IS - 2
ER -