TY - CHAP
T1 - Introduction to ion channels
AU - Di Resta, Chiara
AU - Becchetti, Andrea
PY - 2010
Y1 - 2010
N2 - Ion channels are integral membrane proteins that contain pathways through which ions can flow. By shifting between closed and open conformational states ('gating' process), they control passive ion flow through the plasma membrane. Channels can be gated by membrane potential, or specific ligands, or other agents, such as mechanical stimuli. The efficacy of the gating process and the kinetics of subsequent inactivation or desensitization are regulated by intracellular mechanisms. Many types of membrane channels exist, with different degrees of ion selectivity. By controlling ion fluxes, they typically regulate membrane potential and excitability, shape the action potential, trigger muscle contraction and exocytosis (through Ca2+ influx), regulate cell volume and many other cellular processes. In the first part of the chapter, we give a brief introduction to the main physiological aspects of ion channels, which may not be familiar to molecular biologists. Subsequently, as a reference for later chapters, we summarize the main structural and functional features of the channel-proteins presently known to be related to integrin receptors.
AB - Ion channels are integral membrane proteins that contain pathways through which ions can flow. By shifting between closed and open conformational states ('gating' process), they control passive ion flow through the plasma membrane. Channels can be gated by membrane potential, or specific ligands, or other agents, such as mechanical stimuli. The efficacy of the gating process and the kinetics of subsequent inactivation or desensitization are regulated by intracellular mechanisms. Many types of membrane channels exist, with different degrees of ion selectivity. By controlling ion fluxes, they typically regulate membrane potential and excitability, shape the action potential, trigger muscle contraction and exocytosis (through Ca2+ influx), regulate cell volume and many other cellular processes. In the first part of the chapter, we give a brief introduction to the main physiological aspects of ion channels, which may not be familiar to molecular biologists. Subsequently, as a reference for later chapters, we summarize the main structural and functional features of the channel-proteins presently known to be related to integrin receptors.
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U2 - 10.1007/978-1-4419-6066-5_2
DO - 10.1007/978-1-4419-6066-5_2
M3 - Chapter
C2 - 20549936
AN - SCOPUS:77954678411
SN - 9781441960658
VL - 674
T3 - Advances in Experimental Medicine and Biology
SP - 9
EP - 21
BT - Advances in Experimental Medicine and Biology
ER -