Intron size in mammals: complexity comes to terms with economy

Research output: Contribution to journalArticlepeer-review

Abstract

Different and contrasting models have been proposed to explain intron size evolution in mammals. Here, we demonstrate that intron and intergenic size per se has no adaptive role in gene expression regulation but reflects the need to preserve conserved intronic elements. Although the amount of non-coding functional elements explains the within-genome size variation of intergenic spacers, we show that an additional, additive pressure has been acting on highly expressed introns to reduce the cost of their transcription.

Original languageEnglish
Pages (from-to)20-24
Number of pages5
JournalTrends in Genetics
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 2007

ASJC Scopus subject areas

  • Genetics

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