Intussusceptive microvascular growth in human glioma

Beatrice Nico, Enrico Crivellato, Diego Guidolin, Tiziana Annese, Vito Longo, Nicoletta Finato, Angelo Vacca, Domenico Ribatti

Research output: Contribution to journalArticlepeer-review


Intussusceptive microvascular growth (IMG), which occurs by splitting of the existing vasculature by transluminal pillars or transendothelial bridges, has been demonstrated in several tumors such as colon and mammary carcinomas, melanoma and B-cell non-Hodgkin's lymphomas. In this study, we have correlated in human glioma the extent of angiogenesis, evaluated as microvascular density, the immunoreactivity of tumor cells to vascular endothelial growth factor (VEGF), vessel diameter and IMG to the tumor stage. Results demonstrate for the first time a relationship in human glioma progression between angiogenesis, VEGF immunoreactivity of tumor cells, vessel diameter and the number of connections of intraluminal tissue folds with the opposite vascular wall, expression of IMG and suggest that IMG could be a mechanism of compensatory vascular growth occurring in human glioma. The advantages are that (1) blood vessels are generated more rapidly; (2) it is energetically and metabolically more economic; (3) the capillaries thereby formed are less leaky.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalClinical and Experimental Medicine
Issue number2
Publication statusPublished - Jun 2010


  • Glioblastoma
  • Intussusceptive microvascular growth
  • Tumor growth
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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