Abstract
Intussusceptive microvascular growth (IMG), which occurs by splitting of the existing vasculature by transluminal pillars or transendothelial bridges, has been demonstrated in several tumors such as colon and mammary carcinomas, melanoma and B-cell non-Hodgkin's lymphomas. In this study, we have correlated in human glioma the extent of angiogenesis, evaluated as microvascular density, the immunoreactivity of tumor cells to vascular endothelial growth factor (VEGF), vessel diameter and IMG to the tumor stage. Results demonstrate for the first time a relationship in human glioma progression between angiogenesis, VEGF immunoreactivity of tumor cells, vessel diameter and the number of connections of intraluminal tissue folds with the opposite vascular wall, expression of IMG and suggest that IMG could be a mechanism of compensatory vascular growth occurring in human glioma. The advantages are that (1) blood vessels are generated more rapidly; (2) it is energetically and metabolically more economic; (3) the capillaries thereby formed are less leaky.
| Original language | English |
|---|---|
| Pages (from-to) | 93-98 |
| Number of pages | 6 |
| Journal | Clinical and Experimental Medicine |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 2010 |
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Keywords
- Glioblastoma
- Intussusceptive microvascular growth
- Tumor growth
- Vascular endothelial growth factor
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Intussusceptive microvascular growth in human glioma. / Nico, Beatrice; Crivellato, Enrico; Guidolin, Diego; Annese, Tiziana; Longo, Vito; Finato, Nicoletta; Vacca, Angelo; Ribatti, Domenico.
In: Clinical and Experimental Medicine, Vol. 10, No. 2, 06.2010, p. 93-98.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intussusceptive microvascular growth in human glioma
AU - Nico, Beatrice
AU - Crivellato, Enrico
AU - Guidolin, Diego
AU - Annese, Tiziana
AU - Longo, Vito
AU - Finato, Nicoletta
AU - Vacca, Angelo
AU - Ribatti, Domenico
PY - 2010/6
Y1 - 2010/6
N2 - Intussusceptive microvascular growth (IMG), which occurs by splitting of the existing vasculature by transluminal pillars or transendothelial bridges, has been demonstrated in several tumors such as colon and mammary carcinomas, melanoma and B-cell non-Hodgkin's lymphomas. In this study, we have correlated in human glioma the extent of angiogenesis, evaluated as microvascular density, the immunoreactivity of tumor cells to vascular endothelial growth factor (VEGF), vessel diameter and IMG to the tumor stage. Results demonstrate for the first time a relationship in human glioma progression between angiogenesis, VEGF immunoreactivity of tumor cells, vessel diameter and the number of connections of intraluminal tissue folds with the opposite vascular wall, expression of IMG and suggest that IMG could be a mechanism of compensatory vascular growth occurring in human glioma. The advantages are that (1) blood vessels are generated more rapidly; (2) it is energetically and metabolically more economic; (3) the capillaries thereby formed are less leaky.
AB - Intussusceptive microvascular growth (IMG), which occurs by splitting of the existing vasculature by transluminal pillars or transendothelial bridges, has been demonstrated in several tumors such as colon and mammary carcinomas, melanoma and B-cell non-Hodgkin's lymphomas. In this study, we have correlated in human glioma the extent of angiogenesis, evaluated as microvascular density, the immunoreactivity of tumor cells to vascular endothelial growth factor (VEGF), vessel diameter and IMG to the tumor stage. Results demonstrate for the first time a relationship in human glioma progression between angiogenesis, VEGF immunoreactivity of tumor cells, vessel diameter and the number of connections of intraluminal tissue folds with the opposite vascular wall, expression of IMG and suggest that IMG could be a mechanism of compensatory vascular growth occurring in human glioma. The advantages are that (1) blood vessels are generated more rapidly; (2) it is energetically and metabolically more economic; (3) the capillaries thereby formed are less leaky.
KW - Glioblastoma
KW - Intussusceptive microvascular growth
KW - Tumor growth
KW - Vascular endothelial growth factor
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U2 - 10.1007/s10238-009-0076-7
DO - 10.1007/s10238-009-0076-7
M3 - Article
VL - 10
SP - 93
EP - 98
JO - Zeitschrift für Die Gesamte Experimentelle Medizin
JF - Zeitschrift für Die Gesamte Experimentelle Medizin
SN - 1591-8890
IS - 2
ER -