Intussusceptive microvascular growth in human glioma

Beatrice Nico, Enrico Crivellato, Diego Guidolin, Tiziana Annese, Vito Longo, Nicoletta Finato, Angelo Vacca, Domenico Ribatti

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Intussusceptive microvascular growth (IMG), which occurs by splitting of the existing vasculature by transluminal pillars or transendothelial bridges, has been demonstrated in several tumors such as colon and mammary carcinomas, melanoma and B-cell non-Hodgkin's lymphomas. In this study, we have correlated in human glioma the extent of angiogenesis, evaluated as microvascular density, the immunoreactivity of tumor cells to vascular endothelial growth factor (VEGF), vessel diameter and IMG to the tumor stage. Results demonstrate for the first time a relationship in human glioma progression between angiogenesis, VEGF immunoreactivity of tumor cells, vessel diameter and the number of connections of intraluminal tissue folds with the opposite vascular wall, expression of IMG and suggest that IMG could be a mechanism of compensatory vascular growth occurring in human glioma. The advantages are that (1) blood vessels are generated more rapidly; (2) it is energetically and metabolically more economic; (3) the capillaries thereby formed are less leaky.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalClinical and Experimental Medicine
Volume10
Issue number2
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Glioma
Tumors
Blood Vessels
Growth
Cells
Vascular Endothelial Growth Factor A
Neoplasms
Blood vessels
B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Melanoma
Colon
Economics
Tissue
Breast Neoplasms

Keywords

  • Glioblastoma
  • Intussusceptive microvascular growth
  • Tumor growth
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nico, B., Crivellato, E., Guidolin, D., Annese, T., Longo, V., Finato, N., ... Ribatti, D. (2010). Intussusceptive microvascular growth in human glioma. Clinical and Experimental Medicine, 10(2), 93-98. https://doi.org/10.1007/s10238-009-0076-7

Intussusceptive microvascular growth in human glioma. / Nico, Beatrice; Crivellato, Enrico; Guidolin, Diego; Annese, Tiziana; Longo, Vito; Finato, Nicoletta; Vacca, Angelo; Ribatti, Domenico.

In: Clinical and Experimental Medicine, Vol. 10, No. 2, 06.2010, p. 93-98.

Research output: Contribution to journalArticle

Nico, B, Crivellato, E, Guidolin, D, Annese, T, Longo, V, Finato, N, Vacca, A & Ribatti, D 2010, 'Intussusceptive microvascular growth in human glioma', Clinical and Experimental Medicine, vol. 10, no. 2, pp. 93-98. https://doi.org/10.1007/s10238-009-0076-7
Nico B, Crivellato E, Guidolin D, Annese T, Longo V, Finato N et al. Intussusceptive microvascular growth in human glioma. Clinical and Experimental Medicine. 2010 Jun;10(2):93-98. https://doi.org/10.1007/s10238-009-0076-7
Nico, Beatrice ; Crivellato, Enrico ; Guidolin, Diego ; Annese, Tiziana ; Longo, Vito ; Finato, Nicoletta ; Vacca, Angelo ; Ribatti, Domenico. / Intussusceptive microvascular growth in human glioma. In: Clinical and Experimental Medicine. 2010 ; Vol. 10, No. 2. pp. 93-98.
@article{001713b745eb46e6a81aa3737873573e,
title = "Intussusceptive microvascular growth in human glioma",
abstract = "Intussusceptive microvascular growth (IMG), which occurs by splitting of the existing vasculature by transluminal pillars or transendothelial bridges, has been demonstrated in several tumors such as colon and mammary carcinomas, melanoma and B-cell non-Hodgkin's lymphomas. In this study, we have correlated in human glioma the extent of angiogenesis, evaluated as microvascular density, the immunoreactivity of tumor cells to vascular endothelial growth factor (VEGF), vessel diameter and IMG to the tumor stage. Results demonstrate for the first time a relationship in human glioma progression between angiogenesis, VEGF immunoreactivity of tumor cells, vessel diameter and the number of connections of intraluminal tissue folds with the opposite vascular wall, expression of IMG and suggest that IMG could be a mechanism of compensatory vascular growth occurring in human glioma. The advantages are that (1) blood vessels are generated more rapidly; (2) it is energetically and metabolically more economic; (3) the capillaries thereby formed are less leaky.",
keywords = "Glioblastoma, Intussusceptive microvascular growth, Tumor growth, Vascular endothelial growth factor",
author = "Beatrice Nico and Enrico Crivellato and Diego Guidolin and Tiziana Annese and Vito Longo and Nicoletta Finato and Angelo Vacca and Domenico Ribatti",
year = "2010",
month = "6",
doi = "10.1007/s10238-009-0076-7",
language = "English",
volume = "10",
pages = "93--98",
journal = "Zeitschrift für Die Gesamte Experimentelle Medizin",
issn = "1591-8890",
publisher = "Springer-Verlag Italia",
number = "2",

}

TY - JOUR

T1 - Intussusceptive microvascular growth in human glioma

AU - Nico, Beatrice

AU - Crivellato, Enrico

AU - Guidolin, Diego

AU - Annese, Tiziana

AU - Longo, Vito

AU - Finato, Nicoletta

AU - Vacca, Angelo

AU - Ribatti, Domenico

PY - 2010/6

Y1 - 2010/6

N2 - Intussusceptive microvascular growth (IMG), which occurs by splitting of the existing vasculature by transluminal pillars or transendothelial bridges, has been demonstrated in several tumors such as colon and mammary carcinomas, melanoma and B-cell non-Hodgkin's lymphomas. In this study, we have correlated in human glioma the extent of angiogenesis, evaluated as microvascular density, the immunoreactivity of tumor cells to vascular endothelial growth factor (VEGF), vessel diameter and IMG to the tumor stage. Results demonstrate for the first time a relationship in human glioma progression between angiogenesis, VEGF immunoreactivity of tumor cells, vessel diameter and the number of connections of intraluminal tissue folds with the opposite vascular wall, expression of IMG and suggest that IMG could be a mechanism of compensatory vascular growth occurring in human glioma. The advantages are that (1) blood vessels are generated more rapidly; (2) it is energetically and metabolically more economic; (3) the capillaries thereby formed are less leaky.

AB - Intussusceptive microvascular growth (IMG), which occurs by splitting of the existing vasculature by transluminal pillars or transendothelial bridges, has been demonstrated in several tumors such as colon and mammary carcinomas, melanoma and B-cell non-Hodgkin's lymphomas. In this study, we have correlated in human glioma the extent of angiogenesis, evaluated as microvascular density, the immunoreactivity of tumor cells to vascular endothelial growth factor (VEGF), vessel diameter and IMG to the tumor stage. Results demonstrate for the first time a relationship in human glioma progression between angiogenesis, VEGF immunoreactivity of tumor cells, vessel diameter and the number of connections of intraluminal tissue folds with the opposite vascular wall, expression of IMG and suggest that IMG could be a mechanism of compensatory vascular growth occurring in human glioma. The advantages are that (1) blood vessels are generated more rapidly; (2) it is energetically and metabolically more economic; (3) the capillaries thereby formed are less leaky.

KW - Glioblastoma

KW - Intussusceptive microvascular growth

KW - Tumor growth

KW - Vascular endothelial growth factor

UR - http://www.scopus.com/inward/record.url?scp=77954666686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954666686&partnerID=8YFLogxK

U2 - 10.1007/s10238-009-0076-7

DO - 10.1007/s10238-009-0076-7

M3 - Article

VL - 10

SP - 93

EP - 98

JO - Zeitschrift für Die Gesamte Experimentelle Medizin

JF - Zeitschrift für Die Gesamte Experimentelle Medizin

SN - 1591-8890

IS - 2

ER -