Intussusceptive microvascular growth in tumors

Domenico Ribatti; Valentin Djonov

doi:10.1016/j.canlet.2011.10.040

Intussusceptive microvascular growth in tumors

Domenico Ribatti, Valentin Djonov

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

Intussusception is an alternative to the sprouting mode of angiogenesis. The advantage of this mechanism of vascular growth is that blood vessels are generated more rapidly and the capillaries thereby formed are less leaky. This review article summarizes our current knowledge concerning the role played by intussusceptive microvascular growth in tumor growth. Interestingly, an angiogenic switch from sprouting to intussusceptive angiogenesis occurs after treatment with angiogenesis inhibitors and may be considered as a tumor-protective adaptative response.

Original language	English
Pages (from-to)	126-131
Number of pages	6
Journal	Cancer Letters
Volume	316
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2011.10.040
Publication status	Published - Mar 28 2012

Keywords

Angiogenesis
Erythropoietin
Intussusceptive microvascular growth
Tumor growth
Vascular endothelial growth factor

ASJC Scopus subject areas

Cancer Research
Oncology

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