Intussusceptive microvascular growth in tumors

Domenico Ribatti, Valentin Djonov

Research output: Contribution to journalArticlepeer-review


Intussusception is an alternative to the sprouting mode of angiogenesis. The advantage of this mechanism of vascular growth is that blood vessels are generated more rapidly and the capillaries thereby formed are less leaky. This review article summarizes our current knowledge concerning the role played by intussusceptive microvascular growth in tumor growth. Interestingly, an angiogenic switch from sprouting to intussusceptive angiogenesis occurs after treatment with angiogenesis inhibitors and may be considered as a tumor-protective adaptative response.

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalCancer Letters
Issue number2
Publication statusPublished - Mar 28 2012


  • Angiogenesis
  • Erythropoietin
  • Intussusceptive microvascular growth
  • Tumor growth
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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