TY - JOUR
T1 - Inulin based micelles loaded with curcumin or celecoxib with effective anti-angiogenic activity
AU - Mandracchia, Delia
AU - Tripodo, Giuseppe
AU - Trapani, Adriana
AU - Ruggieri, Simona
AU - Annese, Tiziana
AU - Chlapanidas, Theodora
AU - Trapani, Giuseppe
AU - Ribatti, Domenico
PY - 2016/10/10
Y1 - 2016/10/10
N2 - Curcumin (CUR) and celecoxib (CLX) are two highly hydrophobic drugs which show bioavailability problems due to their poor aqueous solubility. The aim of this study was to encapsulate each of these drugs in micelles based on biodegradable and amphiphilic polymers to investigate their anti-angiogenesis activity. Here we use an amphiphilic polymer, based on two natural substances from renewable resources (Inulin and Vitamin E, INVITE), as a self-assembling system for the drug delivery of CUR and CLX. By the in vivo assay of chick embryo chorioallantoic membrane (CAM) it was assessed that both INVITE-CUR and INVITE-CLX micelles possess remarkable anti-angiogenic activity, while the INVITE micelles alone resulted intrinsically pro-angiogenic. Furthermore, it has been shown that encapsulation of CUR and CLX in INVITE micelles enhances of several magnitudes the water-solubility of CUR and CLX (14·105 and 3·102 times for CUR and CLX, respectively). These results may have interesting implications not only in anticancer or diabetic maculopathy therapy based on the anti-angiogenesis strategy but also for regenerative medicine where over-production of new vessels is required.
AB - Curcumin (CUR) and celecoxib (CLX) are two highly hydrophobic drugs which show bioavailability problems due to their poor aqueous solubility. The aim of this study was to encapsulate each of these drugs in micelles based on biodegradable and amphiphilic polymers to investigate their anti-angiogenesis activity. Here we use an amphiphilic polymer, based on two natural substances from renewable resources (Inulin and Vitamin E, INVITE), as a self-assembling system for the drug delivery of CUR and CLX. By the in vivo assay of chick embryo chorioallantoic membrane (CAM) it was assessed that both INVITE-CUR and INVITE-CLX micelles possess remarkable anti-angiogenic activity, while the INVITE micelles alone resulted intrinsically pro-angiogenic. Furthermore, it has been shown that encapsulation of CUR and CLX in INVITE micelles enhances of several magnitudes the water-solubility of CUR and CLX (14·105 and 3·102 times for CUR and CLX, respectively). These results may have interesting implications not only in anticancer or diabetic maculopathy therapy based on the anti-angiogenesis strategy but also for regenerative medicine where over-production of new vessels is required.
KW - Angiogenesis
KW - Celecoxib
KW - Curcumin
KW - Inulin
KW - Micelle
KW - Vitamin E
UR - http://www.scopus.com/inward/record.url?scp=84982267460&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982267460&partnerID=8YFLogxK
U2 - 10.1016/j.ejps.2016.08.027
DO - 10.1016/j.ejps.2016.08.027
M3 - Article
AN - SCOPUS:84982267460
VL - 93
SP - 141
EP - 196
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
SN - 0928-0987
ER -