Inulin based micelles loaded with curcumin or celecoxib with effective anti-angiogenic activity

Delia Mandracchia, Giuseppe Tripodo, Adriana Trapani, Simona Ruggieri, Tiziana Annese, Theodora Chlapanidas, Giuseppe Trapani, Domenico Ribatti

Research output: Contribution to journalArticle

Abstract

Curcumin (CUR) and celecoxib (CLX) are two highly hydrophobic drugs which show bioavailability problems due to their poor aqueous solubility. The aim of this study was to encapsulate each of these drugs in micelles based on biodegradable and amphiphilic polymers to investigate their anti-angiogenesis activity. Here we use an amphiphilic polymer, based on two natural substances from renewable resources (Inulin and Vitamin E, INVITE), as a self-assembling system for the drug delivery of CUR and CLX. By the in vivo assay of chick embryo chorioallantoic membrane (CAM) it was assessed that both INVITE-CUR and INVITE-CLX micelles possess remarkable anti-angiogenic activity, while the INVITE micelles alone resulted intrinsically pro-angiogenic. Furthermore, it has been shown that encapsulation of CUR and CLX in INVITE micelles enhances of several magnitudes the water-solubility of CUR and CLX (14·105 and 3·102 times for CUR and CLX, respectively). These results may have interesting implications not only in anticancer or diabetic maculopathy therapy based on the anti-angiogenesis strategy but also for regenerative medicine where over-production of new vessels is required.

Original languageEnglish
Pages (from-to)141-196
Number of pages56
JournalEuropean Journal of Pharmaceutical Sciences
Volume93
DOIs
Publication statusPublished - Oct 10 2016

Keywords

  • Angiogenesis
  • Celecoxib
  • Curcumin
  • Inulin
  • Micelle
  • Vitamin E

ASJC Scopus subject areas

  • Pharmaceutical Science

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  • Cite this

    Mandracchia, D., Tripodo, G., Trapani, A., Ruggieri, S., Annese, T., Chlapanidas, T., Trapani, G., & Ribatti, D. (2016). Inulin based micelles loaded with curcumin or celecoxib with effective anti-angiogenic activity. European Journal of Pharmaceutical Sciences, 93, 141-196. https://doi.org/10.1016/j.ejps.2016.08.027