Invasive assessment of bacterial endotoxin and inflammatory cytokines in patients with acute heart failure

Thomas Peschel, Martin Schönauer, Holger Thiele, Stefan Anker, Gerhard Schuler, Josef Niebauer

Research output: Contribution to journalArticle

Abstract

Aims: To test the hypothesis that during acute heart failure endotoxin might be increased in hepatic veins as a sign of bacterial or endotoxin translocation from the bowel into the blood stream. Methods and results: In patients with acute heart failure (NYHA IV; n=17) levels of endotoxin, soluble (s) CD14, tumor necrosis factor α (TNFα and interleukin 6 (IL6)) were measured in blood drawn from an antecubital vein on admission and compared with age-matched patients with stable chronic heart failure (n=21) and healthy volunteers (n=9). All levels were systemically elevated during acute heart failure (all P

Original languageEnglish
Pages (from-to)609-614
Number of pages6
JournalEuropean Journal of Heart Failure
Volume5
Issue number5
DOIs
Publication statusPublished - Oct 2003

Keywords

  • Cytokines
  • Edema
  • Heart failure
  • Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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