Invasive candida infections in neonates after major surgery: Current evidence and new directions

Study Group of Neonatal Infectious Diseases; Domenico Umberto De Rose; Alessandra Santisi; Maria Paola Ronchetti; Ludovica Martini; Lisa Serafini; Pasqua Betta; Marzia Maino; Francesco Cavigioli; Ilaria Cocchi; Lorenza Pugni; Elvira Bonanno; Chryssoula Tzialla; Mario Giuffrè; Jenny Bua; Benedetta Della Torre; Giovanna Nardella; Danila Mazzeo; Paolo Manzoni; Andrea Dotta; Pietro Bagolan; Cinzia Auriti

doi:10.3390/pathogens10030319

Invasive candida infections in neonates after major surgery: Current evidence and new directions

Study Group of Neonatal Infectious Diseases, Domenico Umberto De Rose, Alessandra Santisi, Maria Paola Ronchetti, Ludovica Martini, Lisa Serafini, Pasqua Betta, Marzia Maino, Francesco Cavigioli, Ilaria Cocchi, Lorenza Pugni, Elvira Bonanno, Chryssoula Tzialla, Mario Giuffrè, Jenny Bua, Benedetta Della Torre, Giovanna Nardella, Danila Mazzeo, Paolo Manzoni, Andrea DottaPietro Bagolan, Cinzia Auriti

Research output: Contribution to journal › Review article › peer-review

Abstract

Infections represent a serious health problem in neonates. Invasive Candida infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses. In this review we summarize 19 published studies which provide the prevalence of previous surgery in neonates with invasive Candida infections. We also provide an overview of risk factors for ICIs after major surgery, fungal colonization, and innate defense mechanisms against fungi, as well as the roles of different Candida spp., the epidemiology and costs of ICIs, diagnosis of ICIs, and antifungal prophylaxis and treatment.

Original language	English
Article number	319
Journal	Pathogens
Volume	10
Issue number	3
DOIs	https://doi.org/10.3390/pathogens10030319
Publication status	Published - Mar 2021

Keywords

Antifungal prophylaxis
Invasive Candida infections
Invasive fungal infections
Neonatal surgery
Newborns
Surgery

ASJC Scopus subject areas

Immunology and Allergy
Molecular Biology
Immunology and Microbiology(all)
Microbiology (medical)
Infectious Diseases

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10.3390/pathogens10030319

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Study Group of Neonatal Infectious Diseases, De Rose, D. U., Santisi, A., Ronchetti, M. P., Martini, L., Serafini, L., Betta, P., Maino, M., Cavigioli, F., Cocchi, I., Pugni, L., Bonanno, E., Tzialla, C., Giuffrè, M., Bua, J., Della Torre, B., Nardella, G., Mazzeo, D., Manzoni, P., ... Auriti, C. (2021). Invasive candida infections in neonates after major surgery: Current evidence and new directions. Pathogens, 10(3), [319]. https://doi.org/10.3390/pathogens10030319

Study Group of Neonatal Infectious Diseases, De Rose, DU, Santisi, A, Ronchetti, MP, Martini, L, Serafini, L, Betta, P, Maino, M, Cavigioli, F, Cocchi, I, Pugni, L, Bonanno, E, Tzialla, C, Giuffrè, M, Bua, J, Della Torre, B, Nardella, G, Mazzeo, D, Manzoni, P, Dotta, A , Bagolan, P & Auriti, C 2021, 'Invasive candida infections in neonates after major surgery: Current evidence and new directions', Pathogens, vol. 10, no. 3, 319. https://doi.org/10.3390/pathogens10030319

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abstract = "Infections represent a serious health problem in neonates. Invasive Candida infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses. In this review we summarize 19 published studies which provide the prevalence of previous surgery in neonates with invasive Candida infections. We also provide an overview of risk factors for ICIs after major surgery, fungal colonization, and innate defense mechanisms against fungi, as well as the roles of different Candida spp., the epidemiology and costs of ICIs, diagnosis of ICIs, and antifungal prophylaxis and treatment.",

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AU - Study Group of Neonatal Infectious Diseases

AU - De Rose, Domenico Umberto

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AU - Ronchetti, Maria Paola

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AU - Maino, Marzia

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AU - Pugni, Lorenza

AU - Bonanno, Elvira

AU - Tzialla, Chryssoula

AU - Giuffrè, Mario

AU - Bua, Jenny

AU - Della Torre, Benedetta

AU - Nardella, Giovanna

AU - Mazzeo, Danila

AU - Manzoni, Paolo

AU - Dotta, Andrea

AU - Bagolan, Pietro

AU - Auriti, Cinzia

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N2 - Infections represent a serious health problem in neonates. Invasive Candida infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses. In this review we summarize 19 published studies which provide the prevalence of previous surgery in neonates with invasive Candida infections. We also provide an overview of risk factors for ICIs after major surgery, fungal colonization, and innate defense mechanisms against fungi, as well as the roles of different Candida spp., the epidemiology and costs of ICIs, diagnosis of ICIs, and antifungal prophylaxis and treatment.

AB - Infections represent a serious health problem in neonates. Invasive Candida infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses. In this review we summarize 19 published studies which provide the prevalence of previous surgery in neonates with invasive Candida infections. We also provide an overview of risk factors for ICIs after major surgery, fungal colonization, and innate defense mechanisms against fungi, as well as the roles of different Candida spp., the epidemiology and costs of ICIs, diagnosis of ICIs, and antifungal prophylaxis and treatment.

KW - Antifungal prophylaxis

KW - Invasive Candida infections

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Invasive candida infections in neonates after major surgery: Current evidence and new directions

Abstract

Keywords

ASJC Scopus subject areas

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