Invasive candida infections in neonates after major surgery: Current evidence and new directions

Study Group of Neonatal Infectious Diseases

Research output: Contribution to journalReview articlepeer-review

Abstract

Infections represent a serious health problem in neonates. Invasive Candida infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses. In this review we summarize 19 published studies which provide the prevalence of previous surgery in neonates with invasive Candida infections. We also provide an overview of risk factors for ICIs after major surgery, fungal colonization, and innate defense mechanisms against fungi, as well as the roles of different Candida spp., the epidemiology and costs of ICIs, diagnosis of ICIs, and antifungal prophylaxis and treatment.

Original languageEnglish
Article number319
JournalPathogens
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 2021

Keywords

  • Antifungal prophylaxis
  • Invasive Candida infections
  • Invasive fungal infections
  • Neonatal surgery
  • Newborns
  • Surgery

ASJC Scopus subject areas

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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