TY - JOUR
T1 - Invasive candida infections in neonates after major surgery
T2 - Current evidence and new directions
AU - Study Group of Neonatal Infectious Diseases
AU - De Rose, Domenico Umberto
AU - Santisi, Alessandra
AU - Ronchetti, Maria Paola
AU - Martini, Ludovica
AU - Serafini, Lisa
AU - Betta, Pasqua
AU - Maino, Marzia
AU - Cavigioli, Francesco
AU - Cocchi, Ilaria
AU - Pugni, Lorenza
AU - Bonanno, Elvira
AU - Tzialla, Chryssoula
AU - Giuffrè, Mario
AU - Bua, Jenny
AU - Della Torre, Benedetta
AU - Nardella, Giovanna
AU - Mazzeo, Danila
AU - Manzoni, Paolo
AU - Dotta, Andrea
AU - Bagolan, Pietro
AU - Auriti, Cinzia
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/3
Y1 - 2021/3
N2 - Infections represent a serious health problem in neonates. Invasive Candida infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses. In this review we summarize 19 published studies which provide the prevalence of previous surgery in neonates with invasive Candida infections. We also provide an overview of risk factors for ICIs after major surgery, fungal colonization, and innate defense mechanisms against fungi, as well as the roles of different Candida spp., the epidemiology and costs of ICIs, diagnosis of ICIs, and antifungal prophylaxis and treatment.
AB - Infections represent a serious health problem in neonates. Invasive Candida infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses. In this review we summarize 19 published studies which provide the prevalence of previous surgery in neonates with invasive Candida infections. We also provide an overview of risk factors for ICIs after major surgery, fungal colonization, and innate defense mechanisms against fungi, as well as the roles of different Candida spp., the epidemiology and costs of ICIs, diagnosis of ICIs, and antifungal prophylaxis and treatment.
KW - Antifungal prophylaxis
KW - Invasive Candida infections
KW - Invasive fungal infections
KW - Neonatal surgery
KW - Newborns
KW - Surgery
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U2 - 10.3390/pathogens10030319
DO - 10.3390/pathogens10030319
M3 - Review article
AN - SCOPUS:85102940727
VL - 10
JO - Pathogens
JF - Pathogens
SN - 2076-0817
IS - 3
M1 - 319
ER -