Invasive fungal sinusitis: An effective combined treatment in five haematological patients

Claudia Vener, Maria Carrabba, Nicola S. Fracchiolla, Antonella Costa, Giovanna Fabio, Cinzia Hu, Clara Sina, Claudio Guastella, Lorenzo Pignataro, Giorgio Lambertenghi Deliliers

Research output: Contribution to journalArticlepeer-review

Abstract

Invasive fungal rhinosinusitis (IFR) is a life-threatening infection. Its onset is subtle and a late diagnosis leads to severe complications. Death may occur within a few weeks notwithstanding treatment. We describe a comprehensive pre- and post-operative approach to care for haematological patients with IFR. Five haematological patients with IFR were treated with systemic antifungal therapy and endoscopic surgical debridement of infected tissues, followed by amphotericin-B directly instilled in the sinuses by a new type of ethmoidal drainage. The IFR remitted in all cases; after 32 months of follow-up, three patients are still alive, and two have died of other causes. Two of the patients who experienced IFR progression to the brain at the IFR onset are still alive. The pharmacological and surgical approach with the post-operative local therapy by a new ethmoidal drainage system could support radical antifungal sinus treatment, thus improving the overall survival.

Original languageEnglish
Pages (from-to)1577-1586
Number of pages10
JournalLeukemia and Lymphoma
Volume48
Issue number8
DOIs
Publication statusPublished - Aug 2007

Keywords

  • Antifungal treatment
  • Aspergillus
  • Immunocompromised patients
  • Invasive fungal rhinosinusitis
  • Mucormycosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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