Invasive growth: A genetic program

Alessandra Gentile, Paolo M. Comoglio

Research output: Contribution to journalArticlepeer-review


Invasive growth is defined as a complex biological program which instructs cells to dissociate, migrate, degrade the surrounding matrix, proliferate and survive. Together, these processes account for tissue morphogenesis, homeostasis and repair, and can be aberrantly implemented for cancer dissemination and metastasis. Individual aspects of this process can be controlled by many cytokines and growth factors. However, coordinated regulation of invasive growth as a whole is specifically accomplished by Hepatocyte Growth Factor, a soluble factor which acts through the tyrosine kinase receptor Met. Here we discuss the different biological facets of invasive growth and analyze the intracellular signals which lead to its execution.

Original languageEnglish
Pages (from-to)451-456
Number of pages6
JournalInternational Journal of Developmental Biology
Issue number5-6
Publication statusPublished - 2004


  • HGF
  • Invasive growth
  • Met
  • Tyrosine kinase

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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