Invasive growth: A two-way street for semaphorin signalling

Polo M. Comoglio; Luca Tamagnone; Silvia Giordano

doi:10.1038/ncb1204-1155

Invasive growth: A two-way street for semaphorin signalling

Polo M. Comoglio, Luca Tamagnone, Silvia Giordano

Istituto Oncologico Candiolo

Research output: Contribution to journal › Article › peer-review

Abstract

Growing evidence suggests that semaphorins - known to provide directional cues during axon guidance - also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.

Original language	English
Pages (from-to)	1155-1157
Number of pages	3
Journal	Nature Cell Biology
Volume	6
Issue number	12
DOIs	https://doi.org/10.1038/ncb1204-1155
Publication status	Published - Dec 2004

ASJC Scopus subject areas

Cell Biology

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title = "Invasive growth: A two-way street for semaphorin signalling",

abstract = "Growing evidence suggests that semaphorins - known to provide directional cues during axon guidance - also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.",

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Invasive growth: A two-way street for semaphorin signalling

Abstract

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