Invasive node-negative breast carcinoma: Multivariate analysis of the prognostic value of peritumoral vessel invasion compared with that of conventional clinico-pathologic features

M. Barbareschi, P. Dalla Palma, P. Bevilacqua, S. Maluta, O. Caffo, S. Meli, P. Boracchi, G. Gasparini

Research output: Contribution to journalArticle

Abstract

The prognostic value of the determination of peritumoral vessel invasion (PVI) in node-negative breast cancer (NNBC) patients is still controversial. This is mainly related to the subjective criteria of evaluation of this histologic finding using morphological methods only. In this study, to assess PVI by stricter criteria, we used both conventional morphological and immunocytochemical techniques, using antibodies specific to endothelial cells (i.e. factor VIII-related antigen and the CD-31 antibody). In a series of 233 evaluable NNBC, with a median follow-up of 5 years we found that 11% of the tumors (25 out of 233) were PVI-positive. A weak association was observed only between PVI and tumor size (p=0.076). In univariate analysis PVI significantly predicted relapse-free survival (p=0.0009), but not overall survival (p=0.1208). The odds of relapse and death for patients with PVI-positive carcinomas were 4.36 and 2.24 times higher than for those with PVI-negative tumors. As far as relapse-free survival is concerned tumor size (p=0.0012), histologic grading (p=0.022), estrogen receptor (p=0.016) and progesterone receptor expression (p=0.017) also had a significant prognostic value. Only tumor size significantly predicted over all survival (p=0.0038) in this series. For 5-year relapse-free survival both PVI (p=0.014) and tumor size (p=0.017) were significant and independent prognostic variables by multivariate analysis. Our results demonstrate that PVI and tumor size are important histological features to identify high-risk NNBC patients. Further studies are needed to compare the prognostic significance of PVI and tumor size with that of novel biological prognostic indicators of emerging importance in this neoplasia.

Original languageEnglish
Pages (from-to)2229-2235
Number of pages7
JournalAnticancer Research
Volume14
Issue number5 B
Publication statusPublished - 1994

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Multivariate Analysis
Breast Neoplasms
Neoplasms
Survival
Recurrence
Antibodies
von Willebrand Factor
Progesterone Receptors
Estrogen Receptors
Endothelial Cells
Carcinoma

Keywords

  • Breast carcinoma
  • Peritumoral vessel invasion
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Barbareschi, M., Dalla Palma, P., Bevilacqua, P., Maluta, S., Caffo, O., Meli, S., ... Gasparini, G. (1994). Invasive node-negative breast carcinoma: Multivariate analysis of the prognostic value of peritumoral vessel invasion compared with that of conventional clinico-pathologic features. Anticancer Research, 14(5 B), 2229-2235.

Invasive node-negative breast carcinoma : Multivariate analysis of the prognostic value of peritumoral vessel invasion compared with that of conventional clinico-pathologic features. / Barbareschi, M.; Dalla Palma, P.; Bevilacqua, P.; Maluta, S.; Caffo, O.; Meli, S.; Boracchi, P.; Gasparini, G.

In: Anticancer Research, Vol. 14, No. 5 B, 1994, p. 2229-2235.

Research output: Contribution to journalArticle

Barbareschi, M, Dalla Palma, P, Bevilacqua, P, Maluta, S, Caffo, O, Meli, S, Boracchi, P & Gasparini, G 1994, 'Invasive node-negative breast carcinoma: Multivariate analysis of the prognostic value of peritumoral vessel invasion compared with that of conventional clinico-pathologic features', Anticancer Research, vol. 14, no. 5 B, pp. 2229-2235.
Barbareschi, M. ; Dalla Palma, P. ; Bevilacqua, P. ; Maluta, S. ; Caffo, O. ; Meli, S. ; Boracchi, P. ; Gasparini, G. / Invasive node-negative breast carcinoma : Multivariate analysis of the prognostic value of peritumoral vessel invasion compared with that of conventional clinico-pathologic features. In: Anticancer Research. 1994 ; Vol. 14, No. 5 B. pp. 2229-2235.
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abstract = "The prognostic value of the determination of peritumoral vessel invasion (PVI) in node-negative breast cancer (NNBC) patients is still controversial. This is mainly related to the subjective criteria of evaluation of this histologic finding using morphological methods only. In this study, to assess PVI by stricter criteria, we used both conventional morphological and immunocytochemical techniques, using antibodies specific to endothelial cells (i.e. factor VIII-related antigen and the CD-31 antibody). In a series of 233 evaluable NNBC, with a median follow-up of 5 years we found that 11{\%} of the tumors (25 out of 233) were PVI-positive. A weak association was observed only between PVI and tumor size (p=0.076). In univariate analysis PVI significantly predicted relapse-free survival (p=0.0009), but not overall survival (p=0.1208). The odds of relapse and death for patients with PVI-positive carcinomas were 4.36 and 2.24 times higher than for those with PVI-negative tumors. As far as relapse-free survival is concerned tumor size (p=0.0012), histologic grading (p=0.022), estrogen receptor (p=0.016) and progesterone receptor expression (p=0.017) also had a significant prognostic value. Only tumor size significantly predicted over all survival (p=0.0038) in this series. For 5-year relapse-free survival both PVI (p=0.014) and tumor size (p=0.017) were significant and independent prognostic variables by multivariate analysis. Our results demonstrate that PVI and tumor size are important histological features to identify high-risk NNBC patients. Further studies are needed to compare the prognostic significance of PVI and tumor size with that of novel biological prognostic indicators of emerging importance in this neoplasia.",
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AB - The prognostic value of the determination of peritumoral vessel invasion (PVI) in node-negative breast cancer (NNBC) patients is still controversial. This is mainly related to the subjective criteria of evaluation of this histologic finding using morphological methods only. In this study, to assess PVI by stricter criteria, we used both conventional morphological and immunocytochemical techniques, using antibodies specific to endothelial cells (i.e. factor VIII-related antigen and the CD-31 antibody). In a series of 233 evaluable NNBC, with a median follow-up of 5 years we found that 11% of the tumors (25 out of 233) were PVI-positive. A weak association was observed only between PVI and tumor size (p=0.076). In univariate analysis PVI significantly predicted relapse-free survival (p=0.0009), but not overall survival (p=0.1208). The odds of relapse and death for patients with PVI-positive carcinomas were 4.36 and 2.24 times higher than for those with PVI-negative tumors. As far as relapse-free survival is concerned tumor size (p=0.0012), histologic grading (p=0.022), estrogen receptor (p=0.016) and progesterone receptor expression (p=0.017) also had a significant prognostic value. Only tumor size significantly predicted over all survival (p=0.0038) in this series. For 5-year relapse-free survival both PVI (p=0.014) and tumor size (p=0.017) were significant and independent prognostic variables by multivariate analysis. Our results demonstrate that PVI and tumor size are important histological features to identify high-risk NNBC patients. Further studies are needed to compare the prognostic significance of PVI and tumor size with that of novel biological prognostic indicators of emerging importance in this neoplasia.

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