Inverse association between free insulin-like growth factor-1 and isovolumic relaxation in arterial systemic hypertension

Maurizio Galderisi, Giovanni Vitale, Giovanni Lupoli, Michelangela Barbieri, Gina Varricchio, Carlo Carella, Oreste De Divitiis, Giuseppe Paolisso

Research output: Contribution to journalArticle

Abstract

Several trials have suggested that insulin-like growth factor-1 (IGF-1) may have a pathophysiological role in the development of arterial essential hypertension. To verify the possible association of IGF-1 with left ventricular morphological and functional echocardiographic parameters in hypertension, we studied 40 male patients with newly diagnosed hypertension and 15 normotensive control subjects. Doppler echocardiography was performed and circulating free IGF-1 levels were determined in all subjects. Circulating free IGF-1 levels were higher in hypertensives than in control subjects (P

Original languageEnglish
Pages (from-to)840-845
Number of pages6
JournalHypertension
Volume38
Issue number4
Publication statusPublished - 2001

Keywords

  • Diastole
  • Echocardiography
  • Hypertension, arterial
  • Insulin growth factor
  • Relaxation

ASJC Scopus subject areas

  • Internal Medicine

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    Galderisi, M., Vitale, G., Lupoli, G., Barbieri, M., Varricchio, G., Carella, C., De Divitiis, O., & Paolisso, G. (2001). Inverse association between free insulin-like growth factor-1 and isovolumic relaxation in arterial systemic hypertension. Hypertension, 38(4), 840-845.