Inverse correlation between morning plasma cortisol levels and MMPI psychasthenia and depression scale scores in victims of mobbing with adjustment disorders

Antonio Rocco, Antonio Martocchia, Patrizia Frugoni, Rossella Baldini, Gabriele Sani, Barbara Di Simone Di Giuseppe, Andrea Vairano, Paolo Girardi, Edoardo Monaco, Roberto Tatarelli, Paolo Falaschi

Research output: Contribution to journalArticle

Abstract

Objectives: Evidence in the literature suggests stress-related changes of hypothalamus-pituitary-adrenal (HPA) axis in mobbing. We investigated the association between HPA activity and psychological profiles in mobbing, using a multidisciplinary approach. Design: Forty-eight victims of mobbing were evaluated by a working group of the Departments of Occupational Medicine, Psychiatry and Internal Medicine. After an informed consent, a detailed occupational history, a psychiatric interview with Minnesota Multiphasic Personality Inventory 2 (MMPI-2) administration and a blood sample (8:00 AM) for the determination of basal adrenocorticotropin (ACTH), cortisol and dehydroepiandrosterone sulphate (DHEAS) plasma levels were collected. Twenty-six patients received an overnight dexamethasone (dex) test. Results: Mean ACTH, cortisol and DHEAS levels were within normal ranges. The dex-test response was normal, with a significant hormone suppression (ACTH p

Original languageEnglish
Pages (from-to)610-613
Number of pages4
JournalNeuroendocrinology Letters
Volume28
Issue number5
Publication statusPublished - Oct 2007

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Keywords

  • Adjustment disorder
  • Cortisol
  • Depression
  • Mobbing

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Rocco, A., Martocchia, A., Frugoni, P., Baldini, R., Sani, G., Di Giuseppe, B. D. S., Vairano, A., Girardi, P., Monaco, E., Tatarelli, R., & Falaschi, P. (2007). Inverse correlation between morning plasma cortisol levels and MMPI psychasthenia and depression scale scores in victims of mobbing with adjustment disorders. Neuroendocrinology Letters, 28(5), 610-613.