Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients

Mario Arciello, Salvatore Petta, Valerio Leoni, Gino Iannucci, Giancarlo Labbadia, Carlo Cammà, Antonio Craxì, Clara Balsano

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Hepatitis C virus infection is characterised by enhanced oxidative stress, which can be measured quantitatively by plasma oxysterol concentration. These molecules may affect lipid metabolism through the activation of Liver X Receptors. Hepatitis C virus exploits host lipid metabolism to facilitate its replication and diffusion. In our study we aimed to evaluate and highlight the potential pathogenetic role of oxysterols, 7-ketocholesterol and 7-β-hydroxycholesterol, in hepatitis C virus-related lipid dysmetabolism. Methods: The study was performed in 42 patients with chronic hepatitis C (93% genotype 1b) and 38 non-alcoholic fatty liver disease patients. Plasma oxysterols 7-ketocholesterol and 7-β-hydroxycholesterol were determined by isotope dilution gas chromatography/mass spectrometry. Results: Gas chromatography/mass spectrometry revealed higher 7-ketocholesterol (71.2 ± 77.3 vs 30.4 ± 14.5; p

Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalDigestive and Liver Disease
Volume44
Issue number3
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Hepacivirus
LDL Cholesterol
Hydroxycholesterols
Lipid Metabolism
Gas Chromatography-Mass Spectrometry
Chronic Hepatitis C
Virus Diseases
Isotopes
Oxidative Stress
Genotype
Lipids
Oxysterols
7-ketocholesterol
Liver X Receptors
Non-alcoholic Fatty Liver Disease

Keywords

  • Chronic hepatitis C infection
  • Lipid metabolism
  • Non-alcoholic fatty liver disease
  • Oxidative stress

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Arciello, M., Petta, S., Leoni, V., Iannucci, G., Labbadia, G., Cammà, C., ... Balsano, C. (2012). Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients. Digestive and Liver Disease, 44(3), 245-250. https://doi.org/10.1016/j.dld.2011.10.022

Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients. / Arciello, Mario; Petta, Salvatore; Leoni, Valerio; Iannucci, Gino; Labbadia, Giancarlo; Cammà, Carlo; Craxì, Antonio; Balsano, Clara.

In: Digestive and Liver Disease, Vol. 44, No. 3, 03.2012, p. 245-250.

Research output: Contribution to journalArticle

Arciello, M, Petta, S, Leoni, V, Iannucci, G, Labbadia, G, Cammà, C, Craxì, A & Balsano, C 2012, 'Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients', Digestive and Liver Disease, vol. 44, no. 3, pp. 245-250. https://doi.org/10.1016/j.dld.2011.10.022
Arciello, Mario ; Petta, Salvatore ; Leoni, Valerio ; Iannucci, Gino ; Labbadia, Giancarlo ; Cammà, Carlo ; Craxì, Antonio ; Balsano, Clara. / Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients. In: Digestive and Liver Disease. 2012 ; Vol. 44, No. 3. pp. 245-250.
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