Abstract
Background: Hepatitis C virus infection is characterised by enhanced oxidative stress, which can be measured quantitatively by plasma oxysterol concentration. These molecules may affect lipid metabolism through the activation of Liver X Receptors. Hepatitis C virus exploits host lipid metabolism to facilitate its replication and diffusion. In our study we aimed to evaluate and highlight the potential pathogenetic role of oxysterols, 7-ketocholesterol and 7-β-hydroxycholesterol, in hepatitis C virus-related lipid dysmetabolism. Methods: The study was performed in 42 patients with chronic hepatitis C (93% genotype 1b) and 38 non-alcoholic fatty liver disease patients. Plasma oxysterols 7-ketocholesterol and 7-β-hydroxycholesterol were determined by isotope dilution gas chromatography/mass spectrometry. Results: Gas chromatography/mass spectrometry revealed higher 7-ketocholesterol (71.2 ± 77.3 vs 30.4 ± 14.5; p
| Original language | English |
|---|---|
| Pages (from-to) | 245-250 |
| Number of pages | 6 |
| Journal | Digestive and Liver Disease |
| Volume | 44 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2012 |
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Keywords
- Chronic hepatitis C infection
- Lipid metabolism
- Non-alcoholic fatty liver disease
- Oxidative stress
ASJC Scopus subject areas
- Gastroenterology
- Hepatology
Cite this
Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients. / Arciello, Mario; Petta, Salvatore; Leoni, Valerio; Iannucci, Gino; Labbadia, Giancarlo; Cammà, Carlo; Craxì, Antonio; Balsano, Clara.
In: Digestive and Liver Disease, Vol. 44, No. 3, 03.2012, p. 245-250.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients
AU - Arciello, Mario
AU - Petta, Salvatore
AU - Leoni, Valerio
AU - Iannucci, Gino
AU - Labbadia, Giancarlo
AU - Cammà, Carlo
AU - Craxì, Antonio
AU - Balsano, Clara
PY - 2012/3
Y1 - 2012/3
N2 - Background: Hepatitis C virus infection is characterised by enhanced oxidative stress, which can be measured quantitatively by plasma oxysterol concentration. These molecules may affect lipid metabolism through the activation of Liver X Receptors. Hepatitis C virus exploits host lipid metabolism to facilitate its replication and diffusion. In our study we aimed to evaluate and highlight the potential pathogenetic role of oxysterols, 7-ketocholesterol and 7-β-hydroxycholesterol, in hepatitis C virus-related lipid dysmetabolism. Methods: The study was performed in 42 patients with chronic hepatitis C (93% genotype 1b) and 38 non-alcoholic fatty liver disease patients. Plasma oxysterols 7-ketocholesterol and 7-β-hydroxycholesterol were determined by isotope dilution gas chromatography/mass spectrometry. Results: Gas chromatography/mass spectrometry revealed higher 7-ketocholesterol (71.2 ± 77.3 vs 30.4 ± 14.5; p
AB - Background: Hepatitis C virus infection is characterised by enhanced oxidative stress, which can be measured quantitatively by plasma oxysterol concentration. These molecules may affect lipid metabolism through the activation of Liver X Receptors. Hepatitis C virus exploits host lipid metabolism to facilitate its replication and diffusion. In our study we aimed to evaluate and highlight the potential pathogenetic role of oxysterols, 7-ketocholesterol and 7-β-hydroxycholesterol, in hepatitis C virus-related lipid dysmetabolism. Methods: The study was performed in 42 patients with chronic hepatitis C (93% genotype 1b) and 38 non-alcoholic fatty liver disease patients. Plasma oxysterols 7-ketocholesterol and 7-β-hydroxycholesterol were determined by isotope dilution gas chromatography/mass spectrometry. Results: Gas chromatography/mass spectrometry revealed higher 7-ketocholesterol (71.2 ± 77.3 vs 30.4 ± 14.5; p
KW - Chronic hepatitis C infection
KW - Lipid metabolism
KW - Non-alcoholic fatty liver disease
KW - Oxidative stress
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UR - http://www.scopus.com/inward/citedby.url?scp=84856586374&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2011.10.022
DO - 10.1016/j.dld.2011.10.022
M3 - Article
VL - 44
SP - 245
EP - 250
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 3
ER -