Inverse relationship between anti-SV40 TASA and anti-H-2 cytotoxic responses

C. De Giovanni, S. Grilli, P. L. Lollini, G. Nicoletti, G. Prodi, P. Nanni

Research output: Contribution to journalArticle

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Abstract

The in vitro cytotoxic response against H-2d and H-2b SV40-transformed fibroblasts was studied in a 40-h 3H-proline assay. A very low response against SV40 TASA is associated with the H-2d antigens on target cells: however, SV40-transformed H-2d cells are as immunogenic as SV40-transformed H-2b cells and prime against H-2b target cells. The data concerning in vitro amplification of the anti-SV40 TASA response and the involvement of cyclophosphamide-sensitive suppressor populations confirm the comparable immunogenicity of SV40-transformed H-2d and H-2b cells and cannot account for the haplotype-related behavior observed with SV40-transformed target cells. The study of the response against allogeneic SV40-transformed cells shows the reverse situation: the lower cytotoxic response is now associated with the H-2b antigens on SV40-transformed cells. As suggested by the data presented here, an interaction between SV40 TASA and H-2 antigens might be postulated.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalJournal of Cancer Research and Clinical Oncology
Volume106
Issue number2
DOIs
Publication statusPublished - Oct 1983

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H-2 Antigens
Vulnerable Populations
Proline
Cyclophosphamide
Haplotypes
Fibroblasts
In Vitro Techniques
H antigen

Keywords

  • H-2 haplotype
  • In vitro cytotoxicity
  • SV40 TASA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Inverse relationship between anti-SV40 TASA and anti-H-2 cytotoxic responses. / De Giovanni, C.; Grilli, S.; Lollini, P. L.; Nicoletti, G.; Prodi, G.; Nanni, P.

In: Journal of Cancer Research and Clinical Oncology, Vol. 106, No. 2, 10.1983, p. 117-122.

Research output: Contribution to journalArticle

De Giovanni, C. ; Grilli, S. ; Lollini, P. L. ; Nicoletti, G. ; Prodi, G. ; Nanni, P. / Inverse relationship between anti-SV40 TASA and anti-H-2 cytotoxic responses. In: Journal of Cancer Research and Clinical Oncology. 1983 ; Vol. 106, No. 2. pp. 117-122.
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AU - Prodi, G.

AU - Nanni, P.

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