Inverse relationship between body mass index and mortality in older nursing home residents: A meta-analysis of 19,538 elderly subjects

N. Veronese; E. Cereda; M. Solmi; S. A. Fowler; E. Manzato; S. Maggi; P. Manu; E. Abe; K. Hayashi; J. P. Allard; B. M. Arendt; A. Beck; M. Chan; Y. J P Audrey; W. Y. Lin; H. S. Hsu; C. C. Lin; R. Diekmann; S. Kimyagarov; M. Miller; I. D. Cameron; K. H. Pitkälä; J. Lee; J. Woo; K. Nakamura; D. Smiley; G. Umpierrez; M. Rondanelli; M. Sund-Levander; L. Valentini; K. Schindler; J. Törmä; S. Volpato; G. Zuliani; M. Wong; K. Lok; J. M. Kane; G. Sergi; C. U. Correll

doi:10.1111/obr.12309

Inverse relationship between body mass index and mortality in older nursing home residents: A meta-analysis of 19,538 elderly subjects

N. Veronese, E. Cereda, M. Solmi, S. A. Fowler, E. Manzato, S. Maggi, P. Manu, E. Abe, K. Hayashi, J. P. Allard, B. M. Arendt, A. Beck, M. Chan, Y. J P Audrey, W. Y. Lin, H. S. Hsu, C. C. Lin, R. Diekmann, S. Kimyagarov, M. MillerI. D. Cameron, K. H. Pitkälä, J. Lee, J. Woo, K. Nakamura, D. Smiley, G. Umpierrez, M. Rondanelli, M. Sund-Levander, L. Valentini, K. Schindler, J. Törmä, S. Volpato, G. Zuliani, M. Wong, K. Lok, J. M. Kane, G. Sergi, C. U. Correll

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Body mass index (BMI) and mortality in old adults from the general population have been related in a U-shaped or J-shaped curve. However, limited information is available for elderly nursing home populations, particularly about specific cause of death. A systematic PubMed/EMBASE/CINAHL/SCOPUS search until 31 May 2014 without language restrictions was conducted. As no published study reported mortality in standard BMI groups (2), the most adjusted hazard ratios (HRs) according to a pre-defined list of covariates were obtained from authors and pooled by random-effect model across each BMI category. Out of 342 hits, 20 studies including 19,538 older nursing home residents with 5,223 deaths during a median of 2 years of follow-up were meta-analysed. Compared with normal weight, all-cause mortality HRs were 1.41 (95% CI=1.26-1.58) for underweight, 0.85 (95% CI=0.73-0.99) for overweight and 0.74 (95% CI=0.57-0.96) for obesity. Underweight was a risk factor for higher mortality caused by infections (HR=1.65 [95% CI=1.13-2.40]). RR results corroborated primary HR results, with additionally lower infection-related mortality in overweight and obese than in normal-weight individuals. Like in the general population, underweight is a risk factor for mortality in old nursing home residents. However, uniquely, not only overweight but also obesity is protective, which has relevant nutritional goal implications in this population/setting.

Original language	English
Pages (from-to)	1001-1015
Number of pages	15
Journal	Obesity Reviews
Volume	16
Issue number	11
DOIs	https://doi.org/10.1111/obr.12309
Publication status	Published - Nov 1 2015

Keywords

Body mass index
Elderly
Mortality
Nursing home

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Endocrinology, Diabetes and Metabolism

Access to Document

10.1111/obr.12309

Fingerprint Dive into the research topics of 'Inverse relationship between body mass index and mortality in older nursing home residents: A meta-analysis of 19,538 elderly subjects'. Together they form a unique fingerprint.

Cite this

Veronese, N., Cereda, E., Solmi, M., Fowler, S. A., Manzato, E., Maggi, S., Manu, P., Abe, E., Hayashi, K., Allard, J. P., Arendt, B. M., Beck, A., Chan, M., Audrey, Y. J. P., Lin, W. Y., Hsu, H. S., Lin, C. C., Diekmann, R., Kimyagarov, S., ... Correll, C. U. (2015). Inverse relationship between body mass index and mortality in older nursing home residents: A meta-analysis of 19,538 elderly subjects. Obesity Reviews, 16(11), 1001-1015. https://doi.org/10.1111/obr.12309

Inverse relationship between body mass index and mortality in older nursing home residents : A meta-analysis of 19,538 elderly subjects. / Veronese, N.; Cereda, E.; Solmi, M.; Fowler, S. A.; Manzato, E.; Maggi, S.; Manu, P.; Abe, E.; Hayashi, K.; Allard, J. P.; Arendt, B. M.; Beck, A.; Chan, M.; Audrey, Y. J P; Lin, W. Y.; Hsu, H. S.; Lin, C. C.; Diekmann, R.; Kimyagarov, S.; Miller, M.; Cameron, I. D.; Pitkälä, K. H.; Lee, J.; Woo, J.; Nakamura, K.; Smiley, D.; Umpierrez, G.; Rondanelli, M.; Sund-Levander, M.; Valentini, L.; Schindler, K.; Törmä, J.; Volpato, S.; Zuliani, G.; Wong, M.; Lok, K.; Kane, J. M.; Sergi, G.; Correll, C. U.

In: Obesity Reviews, Vol. 16, No. 11, 01.11.2015, p. 1001-1015.

Research output: Contribution to journal › Article › peer-review

Veronese, N, Cereda, E, Solmi, M, Fowler, SA, Manzato, E, Maggi, S, Manu, P, Abe, E, Hayashi, K, Allard, JP, Arendt, BM, Beck, A, Chan, M, Audrey, YJP, Lin, WY, Hsu, HS, Lin, CC, Diekmann, R, Kimyagarov, S, Miller, M, Cameron, ID, Pitkälä, KH, Lee, J, Woo, J, Nakamura, K, Smiley, D, Umpierrez, G, Rondanelli, M, Sund-Levander, M, Valentini, L, Schindler, K, Törmä, J, Volpato, S, Zuliani, G, Wong, M, Lok, K, Kane, JM, Sergi, G & Correll, CU 2015, 'Inverse relationship between body mass index and mortality in older nursing home residents: A meta-analysis of 19,538 elderly subjects', Obesity Reviews, vol. 16, no. 11, pp. 1001-1015. https://doi.org/10.1111/obr.12309

Veronese, N. ; Cereda, E. ; Solmi, M. ; Fowler, S. A. ; Manzato, E. ; Maggi, S. ; Manu, P. ; Abe, E. ; Hayashi, K. ; Allard, J. P. ; Arendt, B. M. ; Beck, A. ; Chan, M. ; Audrey, Y. J P ; Lin, W. Y. ; Hsu, H. S. ; Lin, C. C. ; Diekmann, R. ; Kimyagarov, S. ; Miller, M. ; Cameron, I. D. ; Pitkälä, K. H. ; Lee, J. ; Woo, J. ; Nakamura, K. ; Smiley, D. ; Umpierrez, G. ; Rondanelli, M. ; Sund-Levander, M. ; Valentini, L. ; Schindler, K. ; Törmä, J. ; Volpato, S. ; Zuliani, G. ; Wong, M. ; Lok, K. ; Kane, J. M. ; Sergi, G. ; Correll, C. U. / Inverse relationship between body mass index and mortality in older nursing home residents : A meta-analysis of 19,538 elderly subjects. In: Obesity Reviews. 2015 ; Vol. 16, No. 11. pp. 1001-1015.

@article{ad5f412f18c94702b49111c2160c4104,

title = "Inverse relationship between body mass index and mortality in older nursing home residents: A meta-analysis of 19,538 elderly subjects",

abstract = "Body mass index (BMI) and mortality in old adults from the general population have been related in a U-shaped or J-shaped curve. However, limited information is available for elderly nursing home populations, particularly about specific cause of death. A systematic PubMed/EMBASE/CINAHL/SCOPUS search until 31 May 2014 without language restrictions was conducted. As no published study reported mortality in standard BMI groups (2), the most adjusted hazard ratios (HRs) according to a pre-defined list of covariates were obtained from authors and pooled by random-effect model across each BMI category. Out of 342 hits, 20 studies including 19,538 older nursing home residents with 5,223 deaths during a median of 2 years of follow-up were meta-analysed. Compared with normal weight, all-cause mortality HRs were 1.41 (95% CI=1.26-1.58) for underweight, 0.85 (95% CI=0.73-0.99) for overweight and 0.74 (95% CI=0.57-0.96) for obesity. Underweight was a risk factor for higher mortality caused by infections (HR=1.65 [95% CI=1.13-2.40]). RR results corroborated primary HR results, with additionally lower infection-related mortality in overweight and obese than in normal-weight individuals. Like in the general population, underweight is a risk factor for mortality in old nursing home residents. However, uniquely, not only overweight but also obesity is protective, which has relevant nutritional goal implications in this population/setting.",

keywords = "Body mass index, Elderly, Mortality, Nursing home",

author = "N. Veronese and E. Cereda and M. Solmi and Fowler, {S. A.} and E. Manzato and S. Maggi and P. Manu and E. Abe and K. Hayashi and Allard, {J. P.} and Arendt, {B. M.} and A. Beck and M. Chan and Audrey, {Y. J P} and Lin, {W. Y.} and Hsu, {H. S.} and Lin, {C. C.} and R. Diekmann and S. Kimyagarov and M. Miller and Cameron, {I. D.} and Pitk{\"a}l{\"a}, {K. H.} and J. Lee and J. Woo and K. Nakamura and D. Smiley and G. Umpierrez and M. Rondanelli and M. Sund-Levander and L. Valentini and K. Schindler and J. T{\"o}rm{\"a} and S. Volpato and G. Zuliani and M. Wong and K. Lok and Kane, {J. M.} and G. Sergi and Correll, {C. U.}",

year = "2015",

month = nov,

day = "1",

doi = "10.1111/obr.12309",

language = "English",

volume = "16",

pages = "1001--1015",

journal = "Obesity Reviews",

issn = "1467-7881",

publisher = "Wiley-Blackwell",

number = "11",

}

TY - JOUR

T1 - Inverse relationship between body mass index and mortality in older nursing home residents

T2 - A meta-analysis of 19,538 elderly subjects

AU - Veronese, N.

AU - Cereda, E.

AU - Solmi, M.

AU - Fowler, S. A.

AU - Manzato, E.

AU - Maggi, S.

AU - Manu, P.

AU - Abe, E.

AU - Hayashi, K.

AU - Allard, J. P.

AU - Arendt, B. M.

AU - Beck, A.

AU - Chan, M.

AU - Audrey, Y. J P

AU - Lin, W. Y.

AU - Hsu, H. S.

AU - Lin, C. C.

AU - Diekmann, R.

AU - Kimyagarov, S.

AU - Miller, M.

AU - Cameron, I. D.

AU - Pitkälä, K. H.

AU - Lee, J.

AU - Woo, J.

AU - Nakamura, K.

AU - Smiley, D.

AU - Umpierrez, G.

AU - Rondanelli, M.

AU - Sund-Levander, M.

AU - Valentini, L.

AU - Schindler, K.

AU - Törmä, J.

AU - Volpato, S.

AU - Zuliani, G.

AU - Wong, M.

AU - Lok, K.

AU - Kane, J. M.

AU - Sergi, G.

AU - Correll, C. U.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Body mass index (BMI) and mortality in old adults from the general population have been related in a U-shaped or J-shaped curve. However, limited information is available for elderly nursing home populations, particularly about specific cause of death. A systematic PubMed/EMBASE/CINAHL/SCOPUS search until 31 May 2014 without language restrictions was conducted. As no published study reported mortality in standard BMI groups (2), the most adjusted hazard ratios (HRs) according to a pre-defined list of covariates were obtained from authors and pooled by random-effect model across each BMI category. Out of 342 hits, 20 studies including 19,538 older nursing home residents with 5,223 deaths during a median of 2 years of follow-up were meta-analysed. Compared with normal weight, all-cause mortality HRs were 1.41 (95% CI=1.26-1.58) for underweight, 0.85 (95% CI=0.73-0.99) for overweight and 0.74 (95% CI=0.57-0.96) for obesity. Underweight was a risk factor for higher mortality caused by infections (HR=1.65 [95% CI=1.13-2.40]). RR results corroborated primary HR results, with additionally lower infection-related mortality in overweight and obese than in normal-weight individuals. Like in the general population, underweight is a risk factor for mortality in old nursing home residents. However, uniquely, not only overweight but also obesity is protective, which has relevant nutritional goal implications in this population/setting.

AB - Body mass index (BMI) and mortality in old adults from the general population have been related in a U-shaped or J-shaped curve. However, limited information is available for elderly nursing home populations, particularly about specific cause of death. A systematic PubMed/EMBASE/CINAHL/SCOPUS search until 31 May 2014 without language restrictions was conducted. As no published study reported mortality in standard BMI groups (2), the most adjusted hazard ratios (HRs) according to a pre-defined list of covariates were obtained from authors and pooled by random-effect model across each BMI category. Out of 342 hits, 20 studies including 19,538 older nursing home residents with 5,223 deaths during a median of 2 years of follow-up were meta-analysed. Compared with normal weight, all-cause mortality HRs were 1.41 (95% CI=1.26-1.58) for underweight, 0.85 (95% CI=0.73-0.99) for overweight and 0.74 (95% CI=0.57-0.96) for obesity. Underweight was a risk factor for higher mortality caused by infections (HR=1.65 [95% CI=1.13-2.40]). RR results corroborated primary HR results, with additionally lower infection-related mortality in overweight and obese than in normal-weight individuals. Like in the general population, underweight is a risk factor for mortality in old nursing home residents. However, uniquely, not only overweight but also obesity is protective, which has relevant nutritional goal implications in this population/setting.

KW - Body mass index

KW - Elderly

KW - Mortality

KW - Nursing home

UR - http://www.scopus.com/inward/record.url?scp=84945437041&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945437041&partnerID=8YFLogxK

U2 - 10.1111/obr.12309

DO - 10.1111/obr.12309

M3 - Article

C2 - 26252230

AN - SCOPUS:84945437041

VL - 16

SP - 1001

EP - 1015

JO - Obesity Reviews

JF - Obesity Reviews

SN - 1467-7881

IS - 11

ER -