Inverse relationship between multiple sclerosis and allergic respiratory diseases

Roberto Bergamaschi, Simona Villani, Massimo Crabbio, Michela Ponzio, Alfredo Romani, Anna Verri, Valeria Bargiggia, Vittorio Cosi

Research output: Contribution to journalArticle

Abstract

Th1 up-regulation seems to favour autoimmunity, while Th2 up-regulation seems to favour humoral immunity. Accordingly, subjects affected by atopic diseases (such as allergic respiratory diseases, ARDs) should be less prone to autoimmune diseases (such as multiple sclerosis, MS), and vice versa. The recent identification of Th17 cells, which seem to favour the development of both autoimmunity and allergy, led to the revision of the classic Th1/Th2 paradigm. We studied 200 MS patients and 200 controls to analyze the relationships between ARDs and MS. MS patients had less probability to suffer from ARDs (OR = 0.30, p <0.001) and allergic rhinitis (OR = 0.25, p <0.001), after adjusting for environmental factors. MS tended to be less severe when associated to ARDs. Our findings add some elements for the comprehension of immune mechanisms involved in MS pathogenesis and suggest to analyze other MS cohorts, in order to evaluate if MS patients affected by allergic diseases show particular clinical findings.

Original languageEnglish
Pages (from-to)115-118
Number of pages4
JournalNeurological Sciences
Volume30
Issue number2
DOIs
Publication statusPublished - 2009

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Multiple Sclerosis
Autoimmunity
Up-Regulation
Th17 Cells
Humoral Immunity
Autoimmune Diseases
Hypersensitivity

Keywords

  • Allergic diseases
  • Asthma
  • Epidemiology
  • Multiple sclerosis
  • Rhinitis
  • Th1/Th2 balance

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

Cite this

Inverse relationship between multiple sclerosis and allergic respiratory diseases. / Bergamaschi, Roberto; Villani, Simona; Crabbio, Massimo; Ponzio, Michela; Romani, Alfredo; Verri, Anna; Bargiggia, Valeria; Cosi, Vittorio.

In: Neurological Sciences, Vol. 30, No. 2, 2009, p. 115-118.

Research output: Contribution to journalArticle

Bergamaschi, R, Villani, S, Crabbio, M, Ponzio, M, Romani, A, Verri, A, Bargiggia, V & Cosi, V 2009, 'Inverse relationship between multiple sclerosis and allergic respiratory diseases', Neurological Sciences, vol. 30, no. 2, pp. 115-118. https://doi.org/10.1007/s10072-009-0036-8
Bergamaschi, Roberto ; Villani, Simona ; Crabbio, Massimo ; Ponzio, Michela ; Romani, Alfredo ; Verri, Anna ; Bargiggia, Valeria ; Cosi, Vittorio. / Inverse relationship between multiple sclerosis and allergic respiratory diseases. In: Neurological Sciences. 2009 ; Vol. 30, No. 2. pp. 115-118.
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