Inversion (11)(p15q22) with NUP98-DDX10 fusion gene in pediatric acute myeloid leukemia

Cristina Morerio, Maura Acquila, Annamaria Rapella, Elisa Tassano, Cristina Rosanda, Claudio Panarello

Research output: Contribution to journalArticlepeer-review

Abstract

The inv(11)(p15q22), a rare but recurrent chromosome abnormality that creates a NUP98-DDX10 fusion gene, is associated with de novo or secondary myeloid malignancies. We report a case of acute monocytic leukemia presenting this rearrangement, studied using fluorescence in situ hybridization (FISH) and reverse transcriptase-PCR (RT-PCR). We also review the cases of inv(11) associated with NUP98-DDX10 reported in the literature.

Original languageEnglish
Pages (from-to)122-125
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume171
Issue number2
DOIs
Publication statusPublished - Dec 2006

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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