Investigating factors associated with adherence behaviour in patients with chronic myeloid leukemia: An observational patient-centered outcome study

F. Efficace, M. Baccarani, G. Rosti, F. Cottone, F. Castagnetti, M. Breccia, G. Alimena, A. Iurlo, A. R. Rossi, S. Pardini, F. Gherlinzoni, M. Salvucci, M. Tiribelli, M. Vignetti, F. Mandelli

Research output: Contribution to journalArticle

Abstract

Background: Optimal adherence to imatinib therapy is of paramount importance to maximise treatment effectiveness in patients with chronic myeloid leukaemia (CML). The main objective of this study was to investigate patient-reported personal factors associated with adherence behaviour. Methods :Analysis was conducted on 413 CML patients receiving long-term therapy with imatinib. Adherence behaviour was measured with the Morisky Medication Adherence Scale and personal factors investigated included: quality of life, perceived social support, fatigue, symptom burden, psychological wellbeing and desire for additional information. Key socio-demographic and treatment-related factors were also taken into account. Univariate and multivariate logistic regression analyses were used to investigate factors associated with optimal adherence to therapy.Results:In all, 53% of patients reported an optimal adherence behaviour. The final multivariate model retained the following variables as independent predictors of optimal adherence to therapy: desire for more information (ref. no), odds ratio (OR)0.43 (95% confidence interval (CI), 0.29-0.66; P

Original languageEnglish
Pages (from-to)904-909
Number of pages6
JournalBritish Journal of Cancer
Volume107
Issue number6
DOIs
Publication statusPublished - Sep 4 2012

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Keywords

  • adherence to therapy
  • chronic myeloid leukaemia
  • quality of life
  • symptoms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Efficace, F., Baccarani, M., Rosti, G., Cottone, F., Castagnetti, F., Breccia, M., Alimena, G., Iurlo, A., Rossi, A. R., Pardini, S., Gherlinzoni, F., Salvucci, M., Tiribelli, M., Vignetti, M., & Mandelli, F. (2012). Investigating factors associated with adherence behaviour in patients with chronic myeloid leukemia: An observational patient-centered outcome study. British Journal of Cancer, 107(6), 904-909. https://doi.org/10.1038/bjc.2012.348