Investigating feed-forward neural regulation of circulation from analysis of spontaneous arterial pressure and heart rate fluctuations

Jacopo M. Legramante, Gianfranco Raimondi, Michele Massaro, Salvatore Cassarino, Giuseppe Peruzzi, Ferdinando Iellamo

Research output: Contribution to journalArticle

Abstract

Background-Analysis of spontaneous fluctuations in systolic arterial pressure (SAP) and pulse interval (PI) reveals the occurrence of sequences of consecutive beats characterized by SAP and PI changing in the same (+PI/+SAP and -PI/-SAP) or opposite (-PI/+SAP and +PI/-SAP) direction. Although the former reflects baroreflex regulatory mechanisms, the physiological meaning of -PI/+SAP and +PI/-SAP is unclear. We tested the hypothesis that -PI/+SAP and +Pi/-SAP 'nonbaroreflex' sequences represent a phenomenon modulated by the autonomic nervous system reflecting a feed-forward mechanism of cardiovascular regulation. Methods and Results-We studied anesthetized rabbits before and after (1) complete autonomic blockade (guanethidine + propranolol + atropine, n = 13; CAB), (2) sympathetic blockade (guanethidine + propranolol, n = 15; SB), (3) parasympathetic blockade (atropine, n= 16), (4) sinoaortic denervation (n= 10; SAD), and (5) controlled respiration (n= 10; CR). Nonbaroreflex sequences were defined as ≥3 beats in which SAP and PI of the following beat changed in the opposite direction. CAB reduced the number of nonbaroreflex sequences (19.1 ± 12.3 versus 88.7 ± 36.6, P

Original languageEnglish
Pages (from-to)1760-1766
Number of pages7
JournalCirculation
Volume99
Issue number13
Publication statusPublished - Apr 6 1999

Keywords

  • Autonomic
  • Baroreceptors
  • Nervous system

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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