TY - JOUR
T1 - Investigating molecular profiles of ovarian cancer
T2 - An update on cancer stem cells
AU - Tomao, Federica
AU - Papa, Anselmo
AU - Martina, Strudel
AU - Rossi, Luigi
AU - Russo, Giuseppe Lo
AU - Panici, Pierluigi Benedetti
AU - Ciabatta, Francesca Romana
AU - Tomao, Silverio
PY - 2014
Y1 - 2014
N2 - Currently we are more and more improving our knowledge about the characteristics and the role of cancer stem cells in human cancer. Particularly we have realized that self-renewing ovarian cancer stem cells (CSCs) or ovarian cancer-initiating cells, and mesenchymal stem cells (SCs) too, are probably implicated in the etiopathogenesis of epithelial ovarian cancer (EOC). There is clear evidence that these cells are also involved in its intra- and extra-peritoneal diffusion and in the occurrence of chemo-resistance. In assessing the molecular characteristics of ovarian CSCs, we have to take note that these cellular populations are rare and the absence of specific cell surface markers represents a challenge to isolate and identify pure SC populations. In our review, we focused our attention on the molecular characteristics of epithelial ovarian CSCs and on the methods to detect them starting from their biological features. The study of ovarian CSCs is taking on an increasingly important strategic role, mostly for the potential therapeutic application in the next future.
AB - Currently we are more and more improving our knowledge about the characteristics and the role of cancer stem cells in human cancer. Particularly we have realized that self-renewing ovarian cancer stem cells (CSCs) or ovarian cancer-initiating cells, and mesenchymal stem cells (SCs) too, are probably implicated in the etiopathogenesis of epithelial ovarian cancer (EOC). There is clear evidence that these cells are also involved in its intra- and extra-peritoneal diffusion and in the occurrence of chemo-resistance. In assessing the molecular characteristics of ovarian CSCs, we have to take note that these cellular populations are rare and the absence of specific cell surface markers represents a challenge to isolate and identify pure SC populations. In our review, we focused our attention on the molecular characteristics of epithelial ovarian CSCs and on the methods to detect them starting from their biological features. The study of ovarian CSCs is taking on an increasingly important strategic role, mostly for the potential therapeutic application in the next future.
KW - Cancer stem cells markers
KW - Epithelial ovarian cancer
KW - Ovarian cancer stem cells
KW - Therapeutic targets
KW - Tumor microenvironment
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U2 - 10.7150/jca.8610
DO - 10.7150/jca.8610
M3 - Article
AN - SCOPUS:84896912505
VL - 5
SP - 301
EP - 310
JO - Journal of Cancer
JF - Journal of Cancer
SN - 1837-9664
IS - 5
ER -