Investigating the functional neuroanatomy of concrete and abstract word processing through direct electric stimulation (DES) during awake surgery

E. F. Orena, D. Caldiroli, F. Acerbi, I. Barazzetta, C. Papagno

Research output: Contribution to journalArticle

Abstract

Neuropsychological, neuroimaging and electrophysiological studies demonstrate that abstract and concrete word processing relies not only on the activity of a common bilateral network but also on dedicated networks. The neuropsychological literature has shown that a selective sparing of abstract relative to concrete words can be documented in lesions of the left anterior temporal regions. We investigated concrete and abstract word processing in 10 patients undergoing direct electrical stimulation (DES) for brain mapping during awake surgery in the left hemisphere. A lexical decision and a concreteness judgment task were added to the neuropsychological assessment during intra-operative monitoring. On the concreteness judgment, DES delivered over the inferior frontal gyrus significantly decreased abstract word accuracy while accuracy for concrete words decreased when the anterior temporal cortex was stimulated. These results are consistent with a lexical–semantic model that distinguishes between concrete and abstract words related to different neural substrates in the left hemisphere.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalCognitive Neuropsychology
DOIs
Publication statusAccepted/In press - Jun 5 2018

Fingerprint

Word Processing
Neuroanatomy
Temporal Lobe
Electric Stimulation
Brain Mapping
Deep Brain Stimulation
Prefrontal Cortex
Neuroimaging
Stimulation
Surgery
Concreteness
Left Hemisphere

Keywords

  • Abstract words
  • direct electrical stimulation
  • left inferior frontal gyrus

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience

Cite this

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