Investigating the mechanisms of cardiovascular and cerebrovascular regulation in orthostatic syncope through an information decomposition strategy

Luca Faes, Alberto Porta, Gianluca Rossato, Alessandro Adami, Davide Tonon, Antonio Corica, Giandomenico Nollo

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Some previous evidence suggests that postural related syncope is associated with defective mechanisms of cerebrovascular (CB) and cardiovascular (CV) control. We characterized the information processing in short-term CB regulation, from the variability of mean cerebral blood flow velocity (CBFV) and mean arterial pressure (AP), and in CV regulation, from the variability of heart period (HP) and systolic AP (SAP), in ten young subjects developing orthostatic syncope in response to prolonged head-up tilt testing. We exploited a novel information-theoretic approach that decomposes the information associated with a variability series into three amounts: the information stored in the series, the information transferred to the series from another series, and the information unexplained by the knowledge of both series. With this approach we were able to show that, compared with the first minutes after head-up tilt, in the period preceding the syncope event (i) the information stored in CBFV variability decreased significantly while the information transferred to CBFV from AP variability increased significantly; (ii) the information storage of HP was kept high but the information transferred to HP from SAP variability decreased significantly. These patterns of information processing suggest that presyncope occurs with a loss both of CB regulation, described by the reduced ability of CBFV of buffering AP fluctuations, and of CV regulation, described by the reduced baroreflex modulation from SAP to HP. We believe that the utilization of tools from the field of information dynamics may give an integrated view of the mechanisms of CB and CV regulation in normal and diseased states, and also provide a deeper understanding of findings revealed by more traditional techniques.

Original languageEnglish
Pages (from-to)76-82
Number of pages7
JournalAutonomic Neuroscience: Basic and Clinical
Volume178
Issue number1-2
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Cerebrovascular Circulation
Blood Flow Velocity
Syncope
Arterial Pressure
Automatic Data Processing
Head
Baroreflex
Information Storage and Retrieval
Blood Pressure

Keywords

  • Baroreflex
  • Cerebral autoregulation
  • Conditional entropy
  • Head-up tilt
  • Information dynamics

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Investigating the mechanisms of cardiovascular and cerebrovascular regulation in orthostatic syncope through an information decomposition strategy. / Faes, Luca; Porta, Alberto; Rossato, Gianluca; Adami, Alessandro; Tonon, Davide; Corica, Antonio; Nollo, Giandomenico.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 178, No. 1-2, 11.2013, p. 76-82.

Research output: Contribution to journalArticle

Faes, Luca ; Porta, Alberto ; Rossato, Gianluca ; Adami, Alessandro ; Tonon, Davide ; Corica, Antonio ; Nollo, Giandomenico. / Investigating the mechanisms of cardiovascular and cerebrovascular regulation in orthostatic syncope through an information decomposition strategy. In: Autonomic Neuroscience: Basic and Clinical. 2013 ; Vol. 178, No. 1-2. pp. 76-82.
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