Investigation and management of IgM and Waldenstrom-associated peripheral neuropathies: recommendations from the IWWM-8 consensus panel

S. D'Sa, M. J. Kersten, J. J. Castillo, M. Dimopoulos, E. Kastritis, E. Laane, V. Leblond, G. Merlini, S. P. Treon, J. M. Vos, M. P. Lunn

Research output: Contribution to journalArticlepeer-review

Abstract

Paraproteinaemic neuropathies are a heterogeneous group of disorders most frequently associated with IgM monoclonal gammopathies including Waldenstrom macroglobulinaemia (WM). Their consequences are significant for affected patients, and their management challenging for their physicians. The variability in clinical presentation and time course hamper classification and management. The indications for invasive investigations such as cerebrospinal fluid analysis, nerve conduction tests and sensory nerve biopsies are unclear, and the optimum way to measure clinical response to treatment unknown. When to intervene and and how to treat, also present challenges to physicians. As part of its latest deliberations at the International Workshops on WM (IWWM) in London, UK (August 2014), the IWWM8 panel have proposed a consensus approach to the diagnosis and management of peripheral neuropathies associated with IgM monoclonal gammopathies, including WM. Importantly, a consensus regarding the use of clinical outcome measures and recommended models of care for this group of patients is discussed, as well as appropriate treatment interventions.
Original languageEnglish
Pages (from-to)728-742
Number of pages15
JournalBritish Journal of Haematology
Volume176
Issue number5
DOIs
Publication statusPublished - Mar 1 2017

Keywords

  • Humans
  • Immunoglobulin M
  • Paraproteinemias/diagnosis/therapy
  • Peripheral Nervous System Diseases/diagnosis/therapy
  • Waldenstrom Macroglobulinemia/diagnosis/therapy
  • IgM
  • Waldenstrom macroglobulinaemia
  • paraproteinaemic neuropathy

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