Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders

Chi Un Pae, Antonio Drago, Martina Forlani, Ashwin A. Patkar, Alessandro Serretti

Research output: Contribution to journalArticlepeer-review


Epistasis, the interaction between genes, is a topic of current interest in molecular and quantitative genetics. We have further studied a previously investigated sample of 187 major depressive disorder (MDD) patients, 171 bipolar disorder (BD) patients, and 288 controls, and tried to analyze the interaction between a set of variations of independent genes: the trace amine receptor 6 (rs4305745, rs8192625, rs7452939, rs6903874, and rs6937506) and the heat shock protein 70 (rs562047, rs1061581, rs2227956). The multifactor dimensionality reduction (MDR) method was applied and the covariates associated with diagnosis were also controlled. A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. The level of statistical significance (P

Original languageEnglish
Pages (from-to)680-683
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number2
Publication statusPublished - Mar 2010


  • Bipolar disorder
  • Epistasis
  • Heat shock proteins
  • Major depressive disorder
  • Trace amines receptor 6

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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