Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders

Chi Un Pae, Antonio Drago, Martina Forlani, Ashwin A. Patkar, Alessandro Serretti

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Epistasis, the interaction between genes, is a topic of current interest in molecular and quantitative genetics. We have further studied a previously investigated sample of 187 major depressive disorder (MDD) patients, 171 bipolar disorder (BD) patients, and 288 controls, and tried to analyze the interaction between a set of variations of independent genes: the trace amine receptor 6 (rs4305745, rs8192625, rs7452939, rs6903874, and rs6937506) and the heat shock protein 70 (rs562047, rs1061581, rs2227956). The multifactor dimensionality reduction (MDR) method was applied and the covariates associated with diagnosis were also controlled. A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. The level of statistical significance (P

Original languageEnglish
Pages (from-to)680-683
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume153
Issue number2
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Mood Disorders
HSP70 Heat-Shock Proteins
Amines
Multifactor Dimensionality Reduction
Genes
Major Depressive Disorder
Bipolar Disorder
Molecular Biology
Genotype

Keywords

  • Bipolar disorder
  • Epistasis
  • Heat shock proteins
  • Major depressive disorder
  • Trace amines receptor 6

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders. / Pae, Chi Un; Drago, Antonio; Forlani, Martina; Patkar, Ashwin A.; Serretti, Alessandro.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 153, No. 2, 03.2010, p. 680-683.

Research output: Contribution to journalArticle

Pae, Chi Un ; Drago, Antonio ; Forlani, Martina ; Patkar, Ashwin A. ; Serretti, Alessandro. / Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2010 ; Vol. 153, No. 2. pp. 680-683.
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