Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura

Mirella Mochi; Sabina Cevoli; Pietro Cortelli; Giulia Pierangeli; Chiara Scapoli; Stefano Soriani; Pasquale Montagna

doi:10.1016/S0022-510X(03)00124-2

Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura

Mirella Mochi, Sabina Cevoli, Pietro Cortelli, Giulia Pierangeli, Chiara Scapoli, Stefano Soriani, Pasquale Montagna

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon 18. The allelic distribution of the (TA)n polymorphism was significantly different between migraine without aura (MO) and both controls and migraine with aura (MA). We suggest a possible predisposition to MO in the studied population through this polymorphism or another polymorphism in linkage disequilibrium with (TA)n.

Original language	English
Pages (from-to)	7-10
Number of pages	4
Journal	Journal of the Neurological Sciences
Volume	213
Issue number	1-2
DOIs	https://doi.org/10.1016/S0022-510X(03)00124-2
Publication status	Published - Sep 15 2003

Keywords

Association study
Chromosome 19
Genetics
LDL receptor
Migraine

ASJC Scopus subject areas

Ageing
Clinical Neurology
Surgery
Neuroscience(all)
Developmental Neuroscience
Neurology

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10.1016/S0022-510X(03)00124-2

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Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura. / Mochi, Mirella; Cevoli, Sabina ; Cortelli, Pietro ; Pierangeli, Giulia; Scapoli, Chiara; Soriani, Stefano; Montagna, Pasquale.

In: Journal of the Neurological Sciences, Vol. 213, No. 1-2, 15.09.2003, p. 7-10.

Research output: Contribution to journal › Article › peer-review

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abstract = "We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon 18. The allelic distribution of the (TA)n polymorphism was significantly different between migraine without aura (MO) and both controls and migraine with aura (MA). We suggest a possible predisposition to MO in the studied population through this polymorphism or another polymorphism in linkage disequilibrium with (TA)n.",

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AU - Mochi, Mirella

AU - Cevoli, Sabina

AU - Cortelli, Pietro

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AU - Scapoli, Chiara

AU - Soriani, Stefano

AU - Montagna, Pasquale

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AB - We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon 18. The allelic distribution of the (TA)n polymorphism was significantly different between migraine without aura (MO) and both controls and migraine with aura (MA). We suggest a possible predisposition to MO in the studied population through this polymorphism or another polymorphism in linkage disequilibrium with (TA)n.

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KW - Chromosome 19

KW - Genetics

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Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura

Abstract

Keywords

ASJC Scopus subject areas

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