Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura

Mirella Mochi, Sabina Cevoli, Pietro Cortelli, Giulia Pierangeli, Chiara Scapoli, Stefano Soriani, Pasquale Montagna

Research output: Contribution to journalArticle

Abstract

We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon 18. The allelic distribution of the (TA)n polymorphism was significantly different between migraine without aura (MO) and both controls and migraine with aura (MA). We suggest a possible predisposition to MO in the studied population through this polymorphism or another polymorphism in linkage disequilibrium with (TA)n.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalJournal of the Neurological Sciences
Volume213
Issue number1-2
DOIs
Publication statusPublished - Sep 15 2003

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Keywords

  • Association study
  • Chromosome 19
  • Genetics
  • LDL receptor
  • Migraine

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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