Investigation of baroreflex autonomic control by spectral coherence of fMRI independent components and neck suction stimulation signal

Matteo Mancini, Eugenio Mattei, Federica Censi, Barbara Basile, Marco Bozzali, Giovanni Calcagnini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Functional Magnetic Resonance Imaging (fMRI) has proved to be a powerful technique for the analysis of the central autonomic control on the cardiovascular system. The carotid stimulation represents a viable non-invasive tool to investigate the brain areas involved in the central autonomic control. In this paper a resting-state fMRI protocol has been carried out on normal subjects, during bilateral carotid stimulation by neck suction using a custom MRI-compliant device. Two suction levels (60 mmHg and 10 mmHg) were applied in two consecutive sessions, using rectangular pulses with a duration of 8 s spaced by 4 s. To detect the brain region involved in processing the carotid baroreceptor efferent signals, a combined approach of independent component analysis (ICA) and spectral coherence (SC) has been used: ICs have been estimated from fMRI data using the GIFT toolbox, the SC between each IC and the neck stimulation signal has been computed, and finally we have identified the stimulus related ICs on the basis of the spectral coherence at the frequency of interest. SC greater than 0.5 were observed in all but one subjects, during the neck suction at 60 mmHg. The SC significantly dropped during the stimulation at 10 mmHg. Frequency analysis of the neck suction stimulation signal in conjunction with ICA of fMRI can identify the brain structures involved in the central processing and integration of afferent signals from the carotid baroreceptors in healthy human subjects.

Original languageEnglish
Title of host publicationComputing in Cardiology
PublisherIEEE Computer Society
Pages1005-1008
Number of pages4
Volume41
EditionJanuary
Publication statusPublished - 2014
Event41st Computing in Cardiology Conference, CinC 2014 - Cambridge, United States
Duration: Sep 7 2014Sep 10 2014

Other

Other41st Computing in Cardiology Conference, CinC 2014
CountryUnited States
CityCambridge
Period9/7/149/10/14

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Computer Science(all)

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