Investigation of biokinetics of radioiodine with a population kinetics approach

T. Janzen, A. Giussani, C. Canzi, P. Gerundini, U. Oeh, C. Hoeschen

Research output: Contribution to journalArticle

Abstract

The dosimetric studies required for planning individually tailored radioiodine therapy of benign thyroid pathologies may be too complex and time-demanding for many ordinary nuclear medicine departments. In this work, a preliminary population kinetics approach was applied to a model structure for iodine biokinetics in order to identify those model features that actually need to be individually investigated, in order to simplify the protocol for data collection in patients. Data from 29 patients undergoing radioiodine therapy for the treatment of the autonomous nodule syndrome were used in the analysis. The greatest inter-individual variations were observed in the parameters describing the transformation of iodide into organic iodine in the thyroid and in the kinetics of the organic form.

Original languageEnglish
Article numberncq054
Pages (from-to)232-235
Number of pages4
JournalRadiation Protection Dosimetry
Volume139
Issue number1-3
DOIs
Publication statusPublished - Feb 19 2010

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation
  • Public Health, Environmental and Occupational Health

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    Janzen, T., Giussani, A., Canzi, C., Gerundini, P., Oeh, U., & Hoeschen, C. (2010). Investigation of biokinetics of radioiodine with a population kinetics approach. Radiation Protection Dosimetry, 139(1-3), 232-235. [ncq054]. https://doi.org/10.1093/rpd/ncq054